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2ejx

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Revision as of 12:10, 10 February 2021

Crystal structure of the hypothetical protein STK_08120 from Sulfolobus tokodaii

Structural highlights

2ejx is a 1 chain structure with sequence from Sulto. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	STK_08120 (SULTO)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

STK_08120 is a member of the thermoacidophile-specific DUF3211 protein family from Sulfolobus tokodaii strain 7. Its molecular function remains obscure, and sequence similarities for obtaining functional remarks are not available. In this study, the crystal structure of STK_08120 was determined at 1.79 A resolution to predict its probable function using structure similarity searches. The structure adopts an alpha/beta structure of a helix-grip fold, which is found in the START domain proteins with cavities for hydrophobic substrates or ligands. The detailed structural features implied that fatty acids are the primary ligand candidates for STK_08120, and binding assays revealed that the protein bound long-chain saturated fatty acids (>C14) and their trans-unsaturated types with an equal affinity to major fatty acid binding proteins in mammals and plants. Moreover, the structure of an STK_08120-myristic acid complex revealed a unique binding mode among fatty acid binding proteins. These results propose that the thermoacidophile-specific protein family DUF3211 functions as a fatty acid carrier with novel binding mode.

A Thermoacidophile-Specific Protein Family, DUF3211, Functions as a Fatty Acid Carrier with Novel Binding Mode.,Miyakawa T, Sawano Y, Miyazono KI, Miyauchi Y, Hatano KI, Tanokura M J Bacteriol. 2013 Jul 8. PMID:23836863^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Miyakawa T, Sawano Y, Miyazono KI, Miyauchi Y, Hatano KI, Tanokura M. A Thermoacidophile-Specific Protein Family, DUF3211, Functions as a Fatty Acid Carrier with Novel Binding Mode. J Bacteriol. 2013 Jul 8. PMID:23836863 doi:10.1128/JB.00432-13

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ejx"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the hypothetical protein STK_08120 from Sulfolobus tokodaii==
-<StructureSection load='2ejx' size='340' side='right' caption='[[2ejx]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
+<StructureSection load='2ejx' size='340' side='right'caption='[[2ejx]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ejx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EJX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ejx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EJX FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STK_08120 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273063 SULTO])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STK_08120 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273063 SULTO])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ejx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ejx OCA], [http://pdbe.org/2ejx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ejx RCSB], [http://www.ebi.ac.uk/pdbsum/2ejx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ejx ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ejx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ejx OCA], [https://pdbe.org/2ejx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ejx RCSB], [https://www.ebi.ac.uk/pdbsum/2ejx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ejx ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 30: / Line 30: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Sulto]]
 [[Category: Hatano, K]]

2ejx

From Proteopedia

Revision as of 12:10, 10 February 2021

Crystal structure of the hypothetical protein STK_08120 from Sulfolobus tokodaii

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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