Regulatory protein E2
From Proteopedia
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| - | <StructureSection load='2ayg' size='340' side='right' caption='Human papillomavirus 6a regulatory protein E2 complex with DNA (PDB code [[2ayg]])' scene='87/873776/Cv/ | + | <StructureSection load='2ayg' size='340' side='right' caption='Human papillomavirus 6a regulatory protein E2 complex with DNA (PDB code [[2ayg]])' scene='87/873776/Cv/2'> |
==Function== | ==Function== | ||
Revision as of 12:59, 10 February 2021
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3D structures of regulatory protein E2
Updated on 10-February-2021
Domains: transactivation (TAD) 2-201; DNA-binding (DBD) 286-365
1r8h, 2aye - RPE2 DBD - HPV6a
2ayb, 2ayg - RPE2 DBD + DNA
1r6k, 1r6n - RPE2 TAD + inhibitor - HPV11
1dto - RPE2 TAD - HPV16
2nnu - RPE2 TAD + BRD4 peptide
1by9, 2q79 - RPE2 DBD
3mi7 - RPE2 DBD (mutant)
1r8p, 1zzf - RPE2 DBD - NMR
1tue - RPE2 TAD + RPE1 - HPV18
1qqh - RPE2 TAD
1f9f - RPE2 DBD
1jj4 - RPE2 DBD + DNA
1dhm - RPE2 DBD - HPV31 - NMR
1a7g - RPE2 DBD - HPV32
2jeu, 2jex - RPE2 TAD (mutant) - BPV1
1jjh, 6bus - RPE2 DBD
1dbd - RPE2 DBD - NMR
2bop - RPE2 DBD + DNA
References
- ↑ Van Horn G, Sheikh S, Khan SA. Regulation of human papillomavirus type 1 replication by the viral E2 protein. Virology. 2001 Aug 15;287(1):214-24. doi: 10.1006/viro.2001.1037. PMID:11504556 doi:http://dx.doi.org/10.1006/viro.2001.1037
- ↑ Singh N, Senapati S, Bose K. Insights into the mechanism of human papillomavirus E2-induced procaspase-8 activation and cell death. Sci Rep. 2016 Feb 24;6:21408. doi: 10.1038/srep21408. PMID:26906543 doi:http://dx.doi.org/10.1038/srep21408
- ↑ Hooley E, Fairweather V, Clarke AR, Gaston K, Brady RL. The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein. Nucleic Acids Res. 2006;34(14):3897-908. Epub 2006 Aug 12. PMID:16914454 doi:10.1093/nar/gkl466
