Regulatory protein E2

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== Structural highlights ==
== Structural highlights ==
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The complex between HPV6a DBD and 18-bp DNA (PDB code [[2ayg]]) shows the binding of 2 recognition helices of the dimer to 2 successive major grooves of the target DNA making numerous contacts to the DNA backbone phosphate atoms and to its bases<ref>PMID:16914454</ref>.
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<scene name='87/873776/Cv/3'>The complex between HPV6a DBD and 18-bp DNA</scene> (PDB code [[2ayg]]) shows the binding of 2 recognition helices of the dimer to 2 successive major grooves of the target DNA making numerous contacts to the DNA backbone phosphate atoms and to its bases<ref>PMID:16914454</ref>.
</StructureSection>
</StructureSection>
==3D structures of regulatory protein E2==
==3D structures of regulatory protein E2==

Current revision

Human papillomavirus 6a regulatory protein E2 complex with DNA (PDB code 2ayg)

Drag the structure with the mouse to rotate

3D structures of regulatory protein E2

Updated on 10-February-2021

Domains: transactivation (TAD) 2-201; DNA-binding (DBD) 286-365

1r8h, 2aye - RPE2 DBD - HPV6a
2ayb, 2ayg - RPE2 DBD + DNA
1r6k, 1r6n - RPE2 TAD + inhibitor - HPV11
1dto - RPE2 TAD - HPV16
2nnu - RPE2 TAD + BRD4 peptide
1by9, 2q79 - RPE2 DBD
3mi7 - RPE2 DBD (mutant)
1r8p, 1zzf - RPE2 DBD - NMR
1tue - RPE2 TAD + RPE1 - HPV18
1qqh - RPE2 TAD
1f9f - RPE2 DBD
1jj4 - RPE2 DBD + DNA
1dhm - RPE2 DBD - HPV31 - NMR
1a7g - RPE2 DBD - HPV32
2jeu, 2jex - RPE2 TAD (mutant) - BPV1
1jjh, 6bus - RPE2 DBD
1dbd - RPE2 DBD - NMR
2bop - RPE2 DBD + DNA

References

  1. ↑ Van Horn G, Sheikh S, Khan SA. Regulation of human papillomavirus type 1 replication by the viral E2 protein. Virology. 2001 Aug 15;287(1):214-24. doi: 10.1006/viro.2001.1037. PMID:11504556 doi:http://dx.doi.org/10.1006/viro.2001.1037
  2. ↑ Singh N, Senapati S, Bose K. Insights into the mechanism of human papillomavirus E2-induced procaspase-8 activation and cell death. Sci Rep. 2016 Feb 24;6:21408. doi: 10.1038/srep21408. PMID:26906543 doi:http://dx.doi.org/10.1038/srep21408
  3. ↑ Hooley E, Fairweather V, Clarke AR, Gaston K, Brady RL. The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein. Nucleic Acids Res. 2006;34(14):3897-908. Epub 2006 Aug 12. PMID:16914454 doi:10.1093/nar/gkl466

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Michal Harel, Alexander Berchansky

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