Sandbox GGC12

==Crystal Structure of Fab12==

<StructureSection load='3ULS' size='340' side='right' caption='Crystal Structure of Fab12' scene=''>

Toll-like Receptors are a part of a family of proteins that consist of ten type 1 transmembrane receptor proteins in human beings. Toll-like Receptor 11 is active in mice with a response to unropathogenic bacteria has been described as not functional in humans. Toll-like receptors that have evolved and are expressed in insects and higher animals. Toll-like receptor proteins mainly have two functional regions. The extracellular domain consists of leucine-rich repeats and one or two cysteine-rich regions that are recognized as an array of microbial components that include sugars, proteins, lipids, DNA motifs, and double-stranded RNA. The intracellular region does consist of a Toll/IL-1 receptor domain, which are like the intracellular domain of the IL-1 receptor. The Toll/IL-1 receptor domain it provides an intracellular scaffold their interacts with several adapter proteins that will initiate and integration as a well-defined signaling cascades resulting in a cellular activation, and the production of a number of cytokines and chemokines <ref>DOI 10.1016/B978-O7216-3695-5.50016-X</ref> or to the article describing Jmol <ref>PMID:22579623</ref> to the rescue.

A rare complication of human herpesvirus 1 (HHV-1) infection, it occurs in only a small minority of HHV-1 infected individuals. There are characterized by a hemorrhagic necrosis of parts from both the temporal and frontal lobes. One of the onsets are that it invloves several days of fear, headache, seizures, stupor, and often coma, frequently with a fatal outcome <ref>PMID:17872438</ref>.

== Relevance ==

TRIF pathway

 

IRF3

Transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role with the innate immune response against DNA and RNA viruses. It will occssionally regulate the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) with their promoters. It would act as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical and significant role in both the early and late phases of the IFNA/B gene induction. There are going to be found in an inactive form within the cytoplasm of uninfected cells and following the viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is going to be phosphorylated by IKBKE and TBK1 kinases. There are going to induce a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages <ref>DOI 10.1038/nri3581</ref> <ref>DOI 10.1016/j.coviro.2011.11.001</ref>.

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. <scene name='78/781196/Sec_structure/2'>This shows the secondary structure</scene> of Crystal Structure of Fab12. Here is a <scene name='78/781196/Ser212/10'>Zoomed in view</scene>name='78/781196/Ser212/2'>Zoomed out view</scene><scene name='78/781196/Ser212/1'>This is Ser212</scene> which is important