1qji
From Proteopedia
(Difference between revisions)
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<StructureSection load='1qji' size='340' side='right'caption='[[1qji]], [[Resolution|resolution]] 2.14Å' scene=''> | <StructureSection load='1qji' size='340' side='right'caption='[[1qji]], [[Resolution|resolution]] 2.14Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1qji]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1qji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Astacus_fluviatilis Astacus fluviatilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QJI FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PKF:CARBOBENZOXY-PRO-LYS-PHE-Y(PO2)-ALA-PRO-OME'>PKF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PKF:CARBOBENZOXY-PRO-LYS-PHE-Y(PO2)-ALA-PRO-OME'>PKF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ast|1ast]], [[1iaa|1iaa]], [[1iab|1iab]], [[1iac|1iac]], [[1iad|1iad]], [[1iae|1iae]], [[1qjj|1qjj]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ast|1ast]], [[1iaa|1iaa]], [[1iab|1iab]], [[1iac|1iac]], [[1iad|1iad]], [[1iae|1iae]], [[1qjj|1qjj]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Astacin Astacin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.21 3.4.24.21] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qji OCA], [https://pdbe.org/1qji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qji RCSB], [https://www.ebi.ac.uk/pdbsum/1qji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qji ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ASTA_ASTAS ASTA_ASTAS]] This protease prefers to cleave in front of small aliphatic residues (P1'). The presence of Lys or Arg in the P1 and P2 position yields high-turnover substrates. In the P3 position the enzyme prefers Pro > Val > Leu > Ala > Gly. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qji ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qji ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Proteinase|Proteinase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:27, 17 February 2021
Structure of astacin with a transition-state analogue inhibitor
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