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1dqt

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[[Image:1dqt.gif|left|200px]]
[[Image:1dqt.gif|left|200px]]
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{{Structure
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|PDB= 1dqt |SIZE=350|CAPTION= <scene name='initialview01'>1dqt</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1dqt", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
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{{STRUCTURE_1dqt| PDB=1dqt | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dqt OCA], [http://www.ebi.ac.uk/pdbsum/1dqt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dqt RCSB]</span>
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'''THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)'''
'''THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)'''
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[[Category: Schwartz, J C.]]
[[Category: Schwartz, J C.]]
[[Category: Shi, W.]]
[[Category: Shi, W.]]
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[[Category: homodimer]]
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[[Category: Homodimer]]
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[[Category: immunoglobulin variable domain-like beta-sandwich]]
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[[Category: Immunoglobulin variable domain-like beta-sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:10:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:46:51 2008''
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Revision as of 11:10, 2 May 2008

Image:1dqt.gif

Template:STRUCTURE 1dqt

THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)


Overview

The effective regulation of T cell responses is dependent on opposing signals transmitted through two related cell-surface receptors, CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Dimerization of CTLA-4 is required for the formation of high-avidity complexes with B7 ligands and for transmission of signals that attenuate T cell activation. We determined the crystal structure of the extracellular portion of CTLA-4 to 2.0 angstrom resolution. CTLA-4 belongs to the immunoglobulin superfamily and displays a strand topology similar to Valpha domains, with an unusual mode of dimerization that places the B7 binding sites distal to the dimerization interface. This organization allows each CTLA-4 dimer to bind two bivalent B7 molecules and suggests that a periodic arrangement of these components within the immunological synapse may contribute to the regulation of T cell responsiveness.

About this Structure

1DQT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of murine CTLA-4 and its role in modulating T cell responsiveness., Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG, Science. 2000 Oct 27;290(5492):816-9. PMID:11052947 Page seeded by OCA on Fri May 2 14:10:06 2008

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