2f5y
From Proteopedia
(Difference between revisions)
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==Crystal Structure of the PDZ Domain from Human RGS-3== | ==Crystal Structure of the PDZ Domain from Human RGS-3== | ||
| - | <StructureSection load='2f5y' size='340' side='right' caption='[[2f5y]], [[Resolution|resolution]] 2.39Å' scene=''> | + | <StructureSection load='2f5y' size='340' side='right'caption='[[2f5y]], [[Resolution|resolution]] 2.39Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2f5y]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2f5y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5Y FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1i92|1i92]], [[1qau|1qau]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1i92|1i92]], [[1qau|1qau]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS3 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5y OCA], [https://pdbe.org/2f5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5y RCSB], [https://www.ebi.ac.uk/pdbsum/2f5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5y ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RGS3_HUMAN RGS3_HUMAN]] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:8602223</ref> <ref>PMID:9858594</ref> <ref>PMID:10749886</ref> <ref>PMID:11294858</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Regulator of G protein signaling|Regulator of G protein signaling]] | + | *[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C]] | [[Category: Arrowsmith, C]] | ||
[[Category: Berridge, G]] | [[Category: Berridge, G]] | ||
Revision as of 10:38, 17 February 2021
Crystal Structure of the PDZ Domain from Human RGS-3
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Categories: Human | Large Structures | Arrowsmith, C | Berridge, G | Bunkoczi, G | Burgess, N | Colebrook, S | Debreczeni, J | Delft, F von | Doyle, D | Edwards, A | Elkins, J | Gorrec, F | Johansson, C | Papagrigoriou, E | Structural genomic | Savitsky, P | Smee, C | Sundstrom, M | Turnbull, A | Ugochukwu, E | Weigelt, J | Yang, X | Pdz domain | Rgs-3 | Sgc | Signaling protein
