Serum amyloid P-component

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Revision as of 11:03, 18 February 2021

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spinqualitylabelsall models Structure of rabphilin-3A C2B domain (green, grey, pink) complex with SNAP-25 N-terminal helix (yellow, magenta), glycerol, sulfate and Ca+2 ions (PDB code 5lob) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Serum amyloid P-component (SAP) is known as a synaptic vesicle-associated protein involved in the regulation of exo- and endocytosis processes at presynaptic sites[1]. Relevance Rab is a major auto antigen in lymphocytic infundibulo-neurohypophysitis (LINH). Antibodies to Rab may serve as a biomarker for the diagnosis of LINH[2]. Structural highlights . Two different are seen. One involves 2 monomers of SNAP-25 and the other involves one monomer[3]. Rab chain A interacts only with SNAP-25 chain D, while Rab chain B interacts with 2 SNAP-25 chains D (residues that interact with Rab chain B are colored salmon) and F.

3D Structures of serum amyloid P-component

Updated on 18-February-2021

1sac – hSAP – human
2a3w, 2a3x, 2a3y – hSAP + bivalent ligand
1gyk – hSAP + galactose derivative
1lgn – hSAP + AMP derivative
2w08 – hSAP + Thr derivative
4avs, 4avt, 4avv, 4ayu – hSAP + Pro derivative
3kqr – hSAP + ethanolamine derivative
3d5o – hSAP + Igg Fc receptor
1qtj – SAP – Limulus polyphemus

References

1. ↑ Stanic J, Carta M, Eberini I, Pelucchi S, Marcello E, Genazzani AA, Racca C, Mulle C, Di Luca M, Gardoni F. Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex. Nat Commun. 2015 Dec 18;6:10181. doi: 10.1038/ncomms10181. PMID:26679993 doi:http://dx.doi.org/10.1038/ncomms10181
2. ↑ Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y. Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis. J Clin Endocrinol Metab. 2015 Jul;100(7):E946-54. doi: 10.1210/jc.2014-4209. Epub, 2015 Apr 28. PMID:25919460 doi:http://dx.doi.org/10.1210/jc.2014-4209
3. ↑ Ferrer-Orta C, Perez-Sanchez MD, Coronado-Parra T, Silva C, Lopez-Martinez D, Baltanas-Copado J, Gomez-Fernandez JC, Corbalan-Garcia S, Verdaguer N. Structural characterization of the Rabphilin-3A-SNAP25 interaction. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5343-E5351. doi:, 10.1073/pnas.1702542114. Epub 2017 Jun 20. PMID:28634303 doi:http://dx.doi.org/10.1073/pnas.1702542114