1dr9

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[[Image:1dr9.gif|left|200px]]
[[Image:1dr9.gif|left|200px]]
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{{Structure
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|PDB= 1dr9 |SIZE=350|CAPTION= <scene name='initialview01'>1dr9</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1dr9", creates the "Structure Box" on the page.
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|GENE= CHO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1dr9| PDB=1dr9 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr9 OCA], [http://www.ebi.ac.uk/pdbsum/1dr9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dr9 RCSB]</span>
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'''CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)'''
'''CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)'''
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[[Category: Jones, E Y.]]
[[Category: Jones, E Y.]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
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[[Category: ig superfamily]]
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[[Category: Ig superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:11:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:47:10 2008''
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Revision as of 11:11, 2 May 2008

Image:1dr9.gif

Template:STRUCTURE 1dr9

CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)


Overview

B7-1 (CD80) and B7-2 (CD86) are glycoproteins expressed on antigen-presenting cells. The binding of these molecules to the T cell homodimers CD28 and CTLA-4 (CD152) generates costimulatory and inhibitory signals in T cells, respectively. The crystal structure of the extracellular region of B7-1 (sB7-1), solved to 3 A resolution, consists of a novel combination of two Ig-like domains, one characteristic of adhesion molecules and the other previously seen only in antigen receptors. In the crystal lattice, sB7-1 unexpectedly forms parallel, 2-fold rotationally symmetric homodimers. Analytical ultracentrifugation reveals that sB7-1 also dimerizes in solution. The structural data suggest a mechanism whereby the avidity-enhanced binding of B7-1 and CTLA-4 homodimers, along with the relatively high affinity of these interactions, favors the formation of very stable inhibitory signaling complexes.

About this Structure

1DR9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and dimerization of a soluble form of B7-1., Ikemizu S, Gilbert RJ, Fennelly JA, Collins AV, Harlos K, Jones EY, Stuart DI, Davis SJ, Immunity. 2000 Jan;12(1):51-60. PMID:10661405 Page seeded by OCA on Fri May 2 14:11:05 2008

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