==Structure of an unliganded and fully-glycosylated SIV gp120 envelope glycoprotein==

<StructureSection load='2bf1' size='340' side='right'caption='[[2bf1]], [[Resolution|resolution]] 4.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[2bf1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BF1 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bf1 OCA], [http://pdbe.org/2bf1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bf1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bf1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bf1 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Envelope glycoproteins of human and simian immunodeficiency virus (HIV and SIV) undergo a series of conformational changes when they interact with receptor (CD4) and co-receptor on the surface of a potential host cell, leading ultimately to fusion of viral and cellular membranes. Structures of fragments of gp120 and gp41 from the envelope protein are known, in conformations corresponding to their post-attachment and postfusion states, respectively. We report the crystal structure, at 4 A resolution, of a fully glycosylated SIV gp120 core, in a conformation representing its prefusion state, before interaction with CD4. Parts of the protein have a markedly different organization than they do in the CD4-bound state. Comparison of the unliganded and CD4-bound structures leads to a model for events that accompany receptor engagement of an envelope glycoprotein trimer. The two conformations of gp120 also present distinct antigenic surfaces. We identify the binding site for a compound that inhibits viral entry.

Structure of an unliganded simian immunodeficiency virus gp120 core.,Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC Nature. 2005 Feb 24;433(7028):834-41. PMID:15729334<ref>PMID:15729334</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2bf1" style="background-color:#fffaf0;"></div>

==See Also==

*[[Gp120|Gp120]]

*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]

== References ==

<references/>

[[Category: Civ]]

[[Category: Chen, B]]

[[Category: Virus protein]]