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2f8b

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==NMR structure of the C-terminal domain (dimer) of HPV45 oncoprotein E7==
==NMR structure of the C-terminal domain (dimer) of HPV45 oncoprotein E7==
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<StructureSection load='2f8b' size='340' side='right' caption='[[2f8b]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='2f8b' size='340' side='right'caption='[[2f8b]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2f8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv45 Hpv45]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F8B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2f8b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hpv45 Hpv45]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F8B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ewl|2ewl]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ewl|2ewl]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10593 HPV45])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10593 HPV45])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8b OCA], [http://pdbe.org/2f8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f8b RCSB], [http://www.ebi.ac.uk/pdbsum/2f8b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8b ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8b OCA], [https://pdbe.org/2f8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f8b RCSB], [https://www.ebi.ac.uk/pdbsum/2f8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VE7_HPV45 VE7_HPV45]] E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
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[[https://www.uniprot.org/uniprot/VE7_HPV45 VE7_HPV45]] E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Hpv45]]
[[Category: Hpv45]]
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[[Category: Large Structures]]
[[Category: Gorlach, M]]
[[Category: Gorlach, M]]
[[Category: Ohlenschlager, O]]
[[Category: Ohlenschlager, O]]

Revision as of 07:13, 24 February 2021

NMR structure of the C-terminal domain (dimer) of HPV45 oncoprotein E7

PDB ID 2f8b

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