1dsz

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[[Image:1dsz.gif|left|200px]]
[[Image:1dsz.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1dsz", creates the "Structure Box" on the page.
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{{STRUCTURE_1dsz| PDB=1dsz | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dsz OCA], [http://www.ebi.ac.uk/pdbsum/1dsz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dsz RCSB]</span>
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'''STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1'''
'''STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1'''
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[[Category: Wagner, T.]]
[[Category: Wagner, T.]]
[[Category: Zhao, Q.]]
[[Category: Zhao, Q.]]
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[[Category: nuclear receptor]]
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[[Category: Nuclear receptor]]
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[[Category: protein-dna]]
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[[Category: Protein-dna]]
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[[Category: rar]]
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[[Category: Rar]]
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[[Category: retinoic acid]]
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[[Category: Retinoic acid]]
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[[Category: rxr]]
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[[Category: Rxr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:14:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:48:05 2008''
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Revision as of 11:14, 2 May 2008

Image:1dsz.gif

Template:STRUCTURE 1dsz

STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1


Overview

The 9-cis retinoic acid receptor (retinoid X receptor, RXR) forms heterodimers with the all-trans retinoic acid receptor (RAR) and other nuclear receptors on DNA regulatory sites composed of tandem binding elements. We describe the 1.70 A resolution structure of the ternary complex of RXR and RAR DNA-binding regions in complex with the retinoic acid response element DR1. The receptors recognize identical half-sites through extensive base-specific contacts; however, RXR binds exclusively to the 3' site to form an asymmetric complex with the reverse polarity of other RXR heterodimers. The subunits associate in a strictly DNA-dependent manner using the T-box of RXR and the Zn-II region of RAR, both of which are reshaped in forming the complex. The protein-DNA contacts, the dimerization interface and the DNA curvature in the RXR-RAR complex are distinct from those of the RXR homodimer, which also binds DR1. Together, these structures illustrate how the nuclear receptor superfamily exploits conformational flexibility and locally induced structures to generate combinatorial transcription factors.

About this Structure

1DSZ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1., Rastinejad F, Wagner T, Zhao Q, Khorasanizadeh S, EMBO J. 2000 Mar 1;19(5):1045-54. PMID:10698945 Page seeded by OCA on Fri May 2 14:14:14 2008

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