PROTAC
From Proteopedia
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| - | PROTAC ( | + | PROTAC (Proteolysis-Targeting Chimera) is a small protein with two active domains joined by a linker. |
[[Image:PROTAC_70.png|thumb|right|300px|Representative PROTAC from [https://protacpedia.weizmann.ac.il/ptcb/detp?i=70 PROTACpedia] targeting EGFR Epidermal growth factor receptor P00533. <span class="bg-lightblue"><b>target binding ligand</b></span><span class="bg-lightmagenta"><b>linker</b></span><span class="bg-lightgreen"><b>E3 binder</b></span>]] | [[Image:PROTAC_70.png|thumb|right|300px|Representative PROTAC from [https://protacpedia.weizmann.ac.il/ptcb/detp?i=70 PROTACpedia] targeting EGFR Epidermal growth factor receptor P00533. <span class="bg-lightblue"><b>target binding ligand</b></span><span class="bg-lightmagenta"><b>linker</b></span><span class="bg-lightgreen"><b>E3 binder</b></span>]] | ||
Revision as of 08:09, 28 February 2021
PROTAC (Proteolysis-Targeting Chimera) is a small protein with two active domains joined by a linker.
Predicting PROTACs
PRosettaC [1] is a computational protocol for the prediction of PROTAC-induced ternary complexes [2]. The protocol receives as input, two protein structures (protein target and E3 ligase), including their appropriate ligands (binders), as well as the PROTAC chemical structure in a SMILES representation, and outputs predicted models for the ternary complex.
PROTACpedia
PROTACpedia [3] is a collaborative and comprehensive, high-quality and freely accessible resource of manually curated data on Proteolysis Targeting Chimeras (PROTACs).
References
- ↑ PRosettaC https://prosettac.weizmann.ac.il
- ↑ Zaidman D, Prilusky J, London N. PRosettaC: Rosetta based modeling of PROTAC mediated ternary complexes. J Chem Inf Model. 2020 Sep 25. doi: 10.1021/acs.jcim.0c00589. PMID:32976709 doi:http://dx.doi.org/10.1021/acs.jcim.0c00589
- ↑ PROTACpedia https://protacpedia.weizmann.ac.il/
