1dud

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1dud.gif|left|200px]]
[[Image:1dud.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1dud |SIZE=350|CAPTION= <scene name='initialview01'>1dud</scene>, resolution 2.3&Aring;
+
The line below this paragraph, containing "STRUCTURE_1dud", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=DUD:DEOXYURIDINE-5&#39;-DIPHOSPHATE'>DUD</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1dud| PDB=1dud | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dud OCA], [http://www.ebi.ac.uk/pdbsum/1dud PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dud RCSB]</span>
+
-
}}
+
'''DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (D-UTPASE) COMPLEXED WITH THE SUBSTRATE ANALOGUE DEOXYURIDINE 5'-DIPHOSPHATE (D-UDP)'''
'''DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (D-UTPASE) COMPLEXED WITH THE SUBSTRATE ANALOGUE DEOXYURIDINE 5'-DIPHOSPHATE (D-UDP)'''
Line 25: Line 22:
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
-
[[Category: dUTP diphosphatase]]
+
[[Category: DUTP diphosphatase]]
[[Category: Larsson, G.]]
[[Category: Larsson, G.]]
[[Category: Nyman, P O.]]
[[Category: Nyman, P O.]]
[[Category: Svensson, L A.]]
[[Category: Svensson, L A.]]
-
[[Category: d-udp complex]]
+
[[Category: D-udp complex]]
-
[[Category: d-utpase]]
+
[[Category: D-utpase]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: nucleotide metabolism]]
+
[[Category: Nucleotide metabolism]]
-
[[Category: substrate analogue]]
+
[[Category: Substrate analogue]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:17:06 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:48:50 2008''
+

Revision as of 11:17, 2 May 2008

Image:1dud.gif

Template:STRUCTURE 1dud

DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (D-UTPASE) COMPLEXED WITH THE SUBSTRATE ANALOGUE DEOXYURIDINE 5'-DIPHOSPHATE (D-UDP)


Overview

We have determined the structure of the homotrimeric dUTPase from Escherichia coli, completed with an inhibitor and substrate analogue, dUDP. Three molecules of dUDP are found symmetrically bound per trimer, each in a shallow cleft between adjacent subunits, interacting with evolutionary conserved residues. The interactions of the uracil ring and the deoxypentose with the protein are consistent with the high specificity of the enzyme with respect to these groups. The positions of the two phosphate groups and adjacent water molecules are discussed in relation to the mechanism and kinetics of catalysis. The role that dUTPase plays in DNA metabolism makes the enzyme a potential target for chemotherapeutic drugs: the results presented here will aid in the design and development of inhibitory compounds.

About this Structure

1DUD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Escherichia coli dUTPase in complex with a substrate analogue (dUDP)., Larsson G, Svensson LA, Nyman PO, Nat Struct Biol. 1996 Jun;3(6):532-8. PMID:8646539 Page seeded by OCA on Fri May 2 14:17:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dud"
Personal tools