1bdg

<StructureSection load='1bdg' size='340' side='right'caption='[[1bdg]], [[Resolution|resolution]] 2.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[1bdg]] is a 1 chain structure. The February 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''The Glycolytic Enzymes'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2004_2 10.2210/rcsb_pdb/mom_2004_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BDG FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bdg OCA], [http://pdbe.org/1bdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bdg RCSB], [http://www.ebi.ac.uk/pdbsum/1bdg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bdg ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane.

The structure of mammalian hexokinase-1.,Mulichak AM, Wilson JE, Padmanabhan K, Garavito RM Nat Struct Biol. 1998 Jul;5(7):555-60. PMID:9665168<ref>PMID:9665168</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1bdg" style="background-color:#fffaf0;"></div>

*[[Hexokinase|Hexokinase]]

[[Category: Hexokinase]]

[[Category: Garavito, R M]]

[[Category: Mulichak, A M]]

[[Category: Phosphotransferase]]