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2fid

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==Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin==
==Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin==
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<StructureSection load='2fid' size='340' side='right' caption='[[2fid]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='2fid' size='340' side='right'caption='[[2fid]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2fid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FID FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2fid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin] and [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FID FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fif|2fif]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fif|2fif]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RABGEF1, RABEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RABGEF1, RABEX5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fid OCA], [http://pdbe.org/2fid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fid RCSB], [http://www.ebi.ac.uk/pdbsum/2fid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fid ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fid OCA], [https://pdbe.org/2fid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fid RCSB], [https://www.ebi.ac.uk/pdbsum/2fid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fid ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RABX5_BOVIN RABX5_BOVIN]] Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.<ref>PMID:9323142</ref> <ref>PMID:16462746</ref>
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[[https://www.uniprot.org/uniprot/RABX5_BOVIN RABX5_BOVIN]] Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.<ref>PMID:9323142</ref> <ref>PMID:16462746</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Rab5 GDP/GTP exchange factor|Rab5 GDP/GTP exchange factor]]
*[[Rab5 GDP/GTP exchange factor|Rab5 GDP/GTP exchange factor]]
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*[[Ubiquitin|Ubiquitin]]
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*[[3D structures of ubiquitin|3D structures of ubiquitin]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Bovin]]
[[Category: Bovin]]
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[[Category: Large Structures]]
[[Category: Hurley, J H]]
[[Category: Hurley, J H]]
[[Category: Lee, S]]
[[Category: Lee, S]]

Revision as of 15:27, 3 March 2021

Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin

PDB ID 2fid

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