4kms
From Proteopedia
(Difference between revisions)
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==Crystal structure of Acetoacetyl-CoA reductase from Rickettsia felis== | ==Crystal structure of Acetoacetyl-CoA reductase from Rickettsia felis== | ||
| - | <StructureSection load='4kms' size='340' side='right' caption='[[4kms]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='4kms' size='340' side='right'caption='[[4kms]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4kms]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4kms]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricfe Ricfe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KMS FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">phbB, RF_015, RF_0153 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">phbB, RF_015, RF_0153 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=315456 RICFE])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kms OCA], [https://pdbe.org/4kms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kms RCSB], [https://www.ebi.ac.uk/pdbsum/4kms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kms ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Rickettsia felis, a Gram-negative bacterium that causes spotted fever, is of increasing interest as an emerging human pathogen. R. felis and several other Rickettsia strains are classed as National Institute of Allergy and Infectious Diseases priority pathogens. In recent years, R. felis has been shown to be adaptable to a wide range of hosts, and many fevers of unknown origin are now being attributed to this infectious agent. Here, the structure of acetoacetyl-CoA reductase from R. felis is reported at a resolution of 2.0 A. While R. felis acetoacetyl-CoA reductase shares less than 50% sequence identity with its closest homologs, it adopts a fold common to other short-chain dehydrogenase/reductase (SDR) family members, such as the fatty-acid synthesis II enzyme FabG from the prominent pathogens Staphylococcus aureus and Bacillus anthracis. Continued characterization of the Rickettsia proteome may prove to be an effective means of finding new avenues of treatment through comparative structural studies. | ||
| + | |||
| + | Crystal structure of acetoacetyl-CoA reductase from Rickettsia felis.,Rodarte JV, Abendroth J, Edwards TE, Lorimer DD, Staker BL, Zhang S, Myler PJ, McLaughlin KJ Acta Crystallogr F Struct Biol Commun. 2021 Feb 1;77(Pt 2):54-60. doi:, 10.1107/S2053230X21001497. Epub 2021 Feb 16. PMID:33620038<ref>PMID:33620038</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4kms" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Ricfe]] | [[Category: Ricfe]] | ||
[[Category: Abendroth, J]] | [[Category: Abendroth, J]] | ||
Revision as of 17:29, 10 March 2021
Crystal structure of Acetoacetyl-CoA reductase from Rickettsia felis
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