7ji3
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Cryo-EM structure of a proton-activated chloride channel== | ==Cryo-EM structure of a proton-activated chloride channel== | ||
| - | <StructureSection load='7ji3' size='340' side='right'caption='[[7ji3]]' scene=''> | + | <StructureSection load='7ji3' size='340' side='right'caption='[[7ji3]], [[Resolution|resolution]] 3.46Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JI3 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ji3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JI3 FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ji3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ji3 OCA], [https://pdbe.org/7ji3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ji3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ji3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ji3 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ji3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ji3 OCA], [https://pdbe.org/7ji3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ji3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ji3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ji3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | TMEM206 has been recently identified as an evolutionarily conserved chloride channel that underlies ubiquitously expressed, proton-activated, outwardly rectifying anion currents. Here, we report the cryo-electron microscopy structure of pufferfish TMEM206, which forms a trimeric channel, with each subunit comprising two transmembrane segments and a large extracellular domain. An ample vestibule in the extracellular region is accessible laterally from the three side portals. The central pore contains multiple constrictions. A conserved lysine residue near the cytoplasmic end of the inner helix forms the presumed chloride ion selectivity filter. Unprecedentedly, the core structure and assembly closely resemble those of the epithelial sodium channel/degenerin family of sodium channels that are unrelated in amino acid sequence and conduct cations instead of anions. Together with electrophysiology, this work provides insights into ion conduction and gating for a new class of chloride channels that is architecturally distinct from previously characterized chloride channel families. | ||
| + | |||
| + | Cryo-EM structure of a proton-activated chloride channel TMEM206.,Deng Z, Zhao Y, Feng J, Zhang J, Zhao H, Rau MJ, Fitzpatrick JAJ, Hu H, Yuan P Sci Adv. 2021 Feb 24;7(9). pii: 7/9/eabe5983. doi: 10.1126/sciadv.abe5983. Print , 2021 Feb. PMID:33627432<ref>PMID:33627432</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7ji3" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Deng Z]] | + | [[Category: Deng, Z]] |
| - | [[Category: Yuan P]] | + | [[Category: Yuan, P]] |
| - | [[Category: Zhang J]] | + | [[Category: Zhang, J]] |
| + | [[Category: Ion channel]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 18:05, 10 March 2021
Cryo-EM structure of a proton-activated chloride channel
| |||||||||||
