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2g8e
From Proteopedia
(Difference between revisions)
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==Calpain 1 proteolytic core in complex with SNJ-1715, a cyclic hemiacetal-type inhibitor== | ==Calpain 1 proteolytic core in complex with SNJ-1715, a cyclic hemiacetal-type inhibitor== | ||
| - | <StructureSection load='2g8e' size='340' side='right' caption='[[2g8e]], [[Resolution|resolution]] 2.25Å' scene=''> | + | <StructureSection load='2g8e' size='340' side='right'caption='[[2g8e]], [[Resolution|resolution]] 2.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2g8e]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2g8e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G8E FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0M6:N-[(2S)-1,4-DIHYDROXYBUTAN-2-YL]-N~2~-(PHENYLCARBAMOTHIOYL)-L-LEUCINAMIDE'>0M6</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0M6:N-[(2S)-1,4-DIHYDROXYBUTAN-2-YL]-N~2~-(PHENYLCARBAMOTHIOYL)-L-LEUCINAMIDE'>0M6</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kxr|1kxr]], [[1tl9|1tl9]], [[1tlo|1tlo]], [[1zcm|1zcm]], [[2g8j|2g8j]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kxr|1kxr]], [[1tl9|1tl9]], [[1tlo|1tlo]], [[1zcm|1zcm]], [[2g8j|2g8j]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Capn1, Cls1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Capn1, Cls1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8e OCA], [https://pdbe.org/2g8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g8e RCSB], [https://www.ebi.ac.uk/pdbsum/2g8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g8e ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CAN1_RAT CAN1_RAT]] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g8e_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g8e_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 2g8e" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2g8e" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Calpain 3D structures|Calpain 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Buffalo rat]] | [[Category: Buffalo rat]] | ||
[[Category: Calpain-1]] | [[Category: Calpain-1]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Campbell, R L]] | [[Category: Campbell, R L]] | ||
[[Category: Cuerrier, D]] | [[Category: Cuerrier, D]] | ||
Revision as of 18:51, 10 March 2021
Calpain 1 proteolytic core in complex with SNJ-1715, a cyclic hemiacetal-type inhibitor
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