This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2gl8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human Retinoic acid receptor RXR-gamma ligand-binding domain== | ==Human Retinoic acid receptor RXR-gamma ligand-binding domain== | ||
| - | <StructureSection load='2gl8' size='340' side='right' caption='[[2gl8]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='2gl8' size='340' side='right'caption='[[2gl8]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2gl8]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2gl8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GL8 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RXRG, NR2B3 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RXRG, NR2B3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gl8 OCA], [https://pdbe.org/2gl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gl8 RCSB], [https://www.ebi.ac.uk/pdbsum/2gl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gl8 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RXRG_HUMAN RXRG_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 21: | Line 21: | ||
==See Also== | ==See Also== | ||
| - | *[[Retinoid X receptor|Retinoid X receptor]] | + | *[[Retinoid X receptor 3D structures|Retinoid X receptor 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bochkarev, A]] | [[Category: Bochkarev, A]] | ||
Revision as of 19:08, 10 March 2021
Human Retinoic acid receptor RXR-gamma ligand-binding domain
| |||||||||||
