Aminoacyl tRNA synthetase 3D structures

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Line 268: Line 268:
* ''Met-RS + tRNA''
* ''Met-RS + tRNA''
- 
**[[2csx]] – AaMetRS + Met-tRNA<br />
**[[2csx]] – AaMetRS + Met-tRNA<br />
Line 408: Line 407:
**[[1ivs]] – TtValRS + Val-SA + Val-tRNA<br />
**[[1ivs]] – TtValRS + Val-SA + Val-tRNA<br />
**[[1gax]] - TtValRS + Val-adenylate analog + Val-tRNA<br />
**[[1gax]] - TtValRS + Val-adenylate analog + Val-tRNA<br />
- 
*Class II aaRS
*Class II aaRS
Line 417: Line 415:
**[[4xeo]] - hAlaRS catalytic domain (mutant)<br />
**[[4xeo]] - hAlaRS catalytic domain (mutant)<br />
**[[5t5s]], [[5t76]] - hAlaRS residues 757-965<br />
**[[5t5s]], [[5t76]] - hAlaRS residues 757-965<br />
 +
**[[6nlq]], [[6nly]], [[6now]] - hAlaRS C-terminal<br />
**[[3g98]] – AaAlaRS residues 758-867<br />
**[[3g98]] – AaAlaRS residues 758-867<br />
**[[1riq]] - AaAlaRS catalytic fragment<br />
**[[1riq]] - AaAlaRS catalytic fragment<br />
Line 451: Line 450:
**[[5gro]] – HpAspRS N terminal<br />
**[[5gro]] – HpAspRS N terminal<br />
**[[4rmf]] – MsAspRS <br />
**[[4rmf]] – MsAspRS <br />
 +
**[[6wom]] – ElAspRS <br />
* ''Asp-RS + small substrates or analogs''
* ''Asp-RS + small substrates or analogs''
Line 466: Line 466:
**[[5y6l]] - hAspRS + MetRS + Glu/ProRS + P18 + P38 <br />
**[[5y6l]] - hAspRS + MetRS + Glu/ProRS + P18 + P38 <br />
 +
**[[6iy6]] - hAspRS + AIMP2 + Glu/ProRS residues 1-157<br />
**[[1il2]], [[1c0a]] – EcAspRS + Asp-tRNA + Asp-adenylate<br />
**[[1il2]], [[1c0a]] – EcAspRS + Asp-tRNA + Asp-adenylate<br />
 +
**[[7ap4]] – TtAspRS + inhibitor<br />
 +
**[[6hhv]], [[6hhw]] – TtAspRS + Asp-SU<br />
 +
**[[6hhx]] – TtAspRS + Asp-SC<br />
 +
**[[6sjc]] – TtAspRS + Asp-SA<br />
**[[4wj4]] – PaAspRS + Asn-tRNA + Asp<br />
**[[4wj4]] – PaAspRS + Asn-tRNA + Asp<br />
**[[4wj3]] – PaAspRS + Asn-tRNA + amidotransferase<br />
**[[4wj3]] – PaAspRS + Asn-tRNA + amidotransferase<br />
Line 476: Line 481:
**[[1x56]] - PhAsnRS<br />
**[[1x56]] - PhAsnRS<br />
**[[2kqr]] – BmAsnRS N-terminal – NMR – ''Brugia malayi''<br />
**[[2kqr]] – BmAsnRS N-terminal – NMR – ''Brugia malayi''<br />
 +
**[[6pqh]] – ElAsnRS<br />
* ''Asn-RS + small substrates or analogs''
* ''Asn-RS + small substrates or analogs''
Line 513: Line 519:
*'''His-RS'''
*'''His-RS'''
-
**[[4x5o]], [[4g84]], [[4g85]] - hHisRS <br />
+
**[[4x5o]], [[4g84]], [[4g85]], [[6o76]] - hHisRS <br />
**[[5w6m]] - hHisRS (mutant)<br />
**[[5w6m]] - hHisRS (mutant)<br />
**[[1x59, [[2lw7]] – hHisRS WHEP-TRS domain - NMR<br />
**[[1x59, [[2lw7]] – hHisRS WHEP-TRS domain - NMR<br />
Line 546: Line 552:
**[[5mgw]], [[5mgh]], [[5mgu]], [[5mgv]] – hPheRS (mutant)<br />
**[[5mgw]], [[5mgh]], [[5mgu]], [[5mgv]] – hPheRS (mutant)<br />
**[[1pys]] – TtPheRS<br />
**[[1pys]] – TtPheRS<br />
-
**[[2cxi]] – PhPheRS chain N-terminal<br />
+
**[[2cxi]] – PhPheRS β chain N-terminal<br />
-
**[[3ica]] – PheRS chain – ''Porphyromonas gingivalis''<br />
+
**[[3ica]] – PheRS β chain – ''Porphyromonas gingivalis''<br />
-
**[[4p71]] – PaPheRS a+ chain<br />
+
**[[4p71]] – PaPheRS α+β chain<br />
-
**[[3ig2]] – PheRS chain – ''Bacterioides fragilis''<br />
+
**[[3ig2]] – PheRS β chain – ''Bacterioides fragilis''<br />
 +
**[[7daw]] – MtPheRS + α+β chains <br />
 +
**[[6p24]] – EcPheRS + α+β chains <br />
* ''Phe-RS + small substrates or analogs''
* ''Phe-RS + small substrates or analogs''
Line 555: Line 563:
**[[3teg]] – hPheRS + L-DOPA<br />
**[[3teg]] – hPheRS + L-DOPA<br />
**[[3pco]] – EcPheRS + phenylalanine+ AMP <br />
**[[3pco]] – EcPheRS + phenylalanine+ AMP <br />
-
**[[3hfz]], [[2amc]] – TtPheRS + chains + Tyr<br />
+
**[[6oz5]], [[6p26]] – EcPheRS α+β chains + inhibitor<br />
-
**[[2akw]], [[1b70]] - TtPheRS + chains + Phe<br />
+
**[[3hfz]], [[2amc]] – TtPheRS α+β chains + Tyr<br />
-
**[[4tva]] - TtPheRS + chains + Phe + puromycin<br />
+
**[[2akw]], [[1b70]] - TtPheRS α+β chains + Phe<br />
-
**[[3teh]] - TtPheRS + chains + L-DOPA<br />
+
**[[4tva]] - TtPheRS α+β chains + Phe + puromycin<br />
-
**[[1jjc]], [[1b7y]] - TtPheRS + chains + Phe-adenylate<br />
+
**[[3teh]] - TtPheRS α+β chains + L-DOPA<br />
-
**[[2aly]] - TtPheRS + chains + Phe-SA<br />
+
**[[1jjc]], [[1b7y]] - TtPheRS α+β chains + Phe-adenylate<br />
-
**[[2rhq]], [[2rhs]] – PheRS + chains (mutant) + inhibitor – ''Staphylococcus haemolyticus''<br />
+
**[[2aly]] - TtPheRS α+β chains + Phe-SA<br />
-
**[[4p72]], [[4p73]], [[4p74]], [[4p75]] – PaPheRS + chains + inhibitor<br />
+
**[[2rhq]], [[2rhs]] – PheRS α+β+ chains (mutant) + inhibitor – ''Staphylococcus haemolyticus''<br />
 +
**[[4p72]], [[4p73]], [[4p74]], [[4p75]] – PaPheRS α+β chains + inhibitor<br />
 +
**[[7db7]], [[7db8]] – MtPheRS α+β chains + inhibitor<br />
 +
**[[6p8t]] – AbPheRS α+β chains + inhibitor<br />
* ''Phe-RS + tRNA''
* ''Phe-RS + tRNA''
**[[3tup]] – hPheRS + Phe-tRNA<br />
**[[3tup]] – hPheRS + Phe-tRNA<br />
-
**[[1eiy]] - TtPheRS + chains + Phe-tRNA<br />
+
**[[1eiy]] - TtPheRS α+β chains + Phe-tRNA<br />
-
**[[2iy5]] - TtPheRS + chains + Phe-ol + Phe-tRNA<br />
+
**[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA<br />
*'''Pro-RS'''
*'''Pro-RS'''
Line 576: Line 587:
**[[1nj2]] - MtProRS –'' Methanothermobacter thermautotrophicus''<br />
**[[1nj2]] - MtProRS –'' Methanothermobacter thermautotrophicus''<br />
**[[1nj8]] – MjProRS<br />
**[[1nj8]] – MjProRS<br />
-
**[[5xif]] – TgProRS residues 334-830 <br />
+
**[[5xif]], [[6aa0]] – TgProRS residues 334-830 <br />
**[[5ucm]] – PaProRS <br />
**[[5ucm]] – PaProRS <br />
**[[4twa]], [[4ncx]] – PfProRS residues 249-746 <br />
**[[4twa]], [[4ncx]] – PfProRS residues 249-746 <br />
Line 599: Line 610:
**[[5f9y]] – CpProRS residues 186-688 + proline + AMP<br />
**[[5f9y]] – CpProRS residues 186-688 + proline + AMP<br />
**[[5xio]] – CpProRS residues 225-719 + halofuginone + ANP <br />
**[[5xio]] – CpProRS residues 225-719 + halofuginone + ANP <br />
-
**[[6nab]] - ProRS + Pro + AMP – Naegleria fowleri<br />
+
**[[5znj]] – SaProRS + halofuginone + ANP <br />
 +
**[[5znk]] – SaProRS + inhibitor + ANP <br />
 +
**[[6nab]] - NfProRS + Pro + AMP – ''Naegleria fowleri''<br />
 +
**[[6uyh]] – NfProRS + halofuginone + ANP <br />
**[[5xiq]] – TgProRS residues 334-830 + halofuginone + ANP <br />
**[[5xiq]] – TgProRS residues 334-830 + halofuginone + ANP <br />
-
**[[5xik]] – TgProRS residues 334-830 + febrifugine derivative + ANP <br />
+
**[[5xik]], [[6a88]] – TgProRS residues 334-830 + febrifugine derivative + ANP <br />
**[[5xig]], [[5xih]], [[5xij]] – TgProRS residues 334-830 + inhibitor + ANP <br />
**[[5xig]], [[5xih]], [[5xij]] – TgProRS residues 334-830 + inhibitor + ANP <br />
**[[5xii]] – TgProRS residues 334-830 (mutant) + inhibitor + ANP <br />
**[[5xii]] – TgProRS residues 334-830 (mutant) + inhibitor + ANP <br />
**[[4ydq]], [[4q15]], [[4olf]] – PfProRS residues 254-746 + halofuginone + AMPPNP <br />
**[[4ydq]], [[4q15]], [[4olf]] – PfProRS residues 254-746 + halofuginone + AMPPNP <br />
 +
**[[6t7k]] – PfProRS residues 254-746 + inhibitor <br />
*'''Bifunctional RS''' (bifunctional glutamate/proline tRNA ligase)
*'''Bifunctional RS''' (bifunctional glutamate/proline tRNA ligase)
-
**[[4hvc]] – hEPRS residues 1003-1513 + halofunginone + ATP analog<br />
+
**[[4hvc]] – hGlu/ProRS residues 1003-1513 + halofunginone + ATP analog<br />
-
**[[5v58]] – hEPRS residues 1003-1513 + AZ-SA<br />
+
**[[5v58]] – hGlu/ProRS residues 1003-1513 + AZ-SA<br />
-
**[[5vad]] – hEPRS residues 1003-1513 + inhibitor<br />
+
**[[5vad]] – hGlu/ProRS residues 1003-1513 + inhibitor<br />
-
**[[5a1n]], [[5a34]], [[5a5h]] – hEPRS GST-like domain + EPRS-AIMP2<br />
+
**[[5a1n]], [[5a34]], [[5a5h]] – hGlu/ProRS GST-like domain + EPRS-AIMP2<br />
 +
**[[1fyj]] – hGlu/ProRS 677-733 – NMR<br />, [[6
*'''Pyrrolysyl-RS'''; domains – RNA-binding 1-101; catalytic 188-454
*'''Pyrrolysyl-RS'''; domains – RNA-binding 1-101; catalytic 188-454
Line 618: Line 634:
**[[3vqw]], [[3vqx]], [[4cs2]] - MmPylRS catalytic domain (mutant)<br />
**[[3vqw]], [[3vqx]], [[4cs2]] - MmPylRS catalytic domain (mutant)<br />
**[[3dsq]] – DhPylRS<br />
**[[3dsq]] – DhPylRS<br />
-
**[[6ezd]] – PylRS – ''Methanomethylophilus alvus''<br />
+
**[[6ezd]], [[6jp2]] – PylRS – ''Methanomethylophilus alvus''<br />
*''Pyrrolysyl-RS binary complex''
*''Pyrrolysyl-RS binary complex''
Line 643: Line 659:
**[[4tqd]] - MmPylRS catalytic domain + iodo-Phe + ATP <br />
**[[4tqd]] - MmPylRS catalytic domain + iodo-Phe + ATP <br />
**[[4tqf]], [[4zib]] - MmPylRS catalytic domain + bromothienylo-Ala + ATP <br />
**[[4tqf]], [[4zib]] - MmPylRS catalytic domain + bromothienylo-Ala + ATP <br />
 +
**[[6ly3]], [[6ly6]], [[6lyb]] - MmPylRS catalytic domain (mutant) + Ala derivative+ ANP <br />
 +
**[[6ly7]], [[6lya]] - MmPylRS catalytic domain (mutant) + Trp derivative + ANP <br />
**[[2zin]] - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog <br />
**[[2zin]] - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog <br />
 +
**[[6aac]], [[6aad]], [[6aao]], [[6aap]], [[6aaz]], [[6ab0]], [[6ab1]], [[6ab2]], [[6ab8]], [[6abk]], [[6abl]], [[6abm]], [[6aan]], [[6anq]] - MmPylRS catalytic domain + azanyl derivative + ATP <br />
*'''Ser-RS'''
*'''Ser-RS'''
**[[3vbb]] - hSerRS <br />
**[[3vbb]] - hSerRS <br />
 +
**[[6gir]] - SerRS – ''Arabidopsis thaliana'' <br />
**[[3lsq]] – TbSerRS <br />
**[[3lsq]] – TbSerRS <br />
**[[1sry]] - TtSerRS<br />
**[[1sry]] - TtSerRS<br />
Line 655: Line 675:
**[[2dq3]] – AaSerRS<br />
**[[2dq3]] – AaSerRS<br />
**[[2du7]] – MjSerRS<br />
**[[2du7]] – MjSerRS<br />
-
**[[2odr]] – SerRS – ''Methanococcus maripaludis''<br />
+
**[[2odr]] – MemSerRS – ''Methanococcus maripaludis''<br />
**[[2cim]] – MbSerRS – ''Methanosarcina barkeri''<br />
**[[2cim]] – MbSerRS – ''Methanosarcina barkeri''<br />
-
**[[1wle]] – SerRS – bovine<br />
 
-
**[[6gir]] - SerRS – ''Arabidopsis thaliana'' <br />
 
**[[3qne]], [[3qo5]], [[3qo7]], [[3qo8]] - CaSerRS <br />
**[[3qne]], [[3qo5]], [[3qo7]], [[3qo8]] - CaSerRS <br />
* ''Ser-RS + small substrates or analogs''
* ''Ser-RS + small substrates or analogs''
**[[4l87]] - hSerRS + Ser-SA<br />
**[[4l87]] - hSerRS + Ser-SA<br />
 +
**[[1wle]] – bSerRS + Ser-adenylate - bovine<br />
**[[2zr2]] – PhSerRS + ATP<br />
**[[2zr2]] – PhSerRS + ATP<br />
**[[2dq0]] – PhSerRS + Ser-SA<br />
**[[2dq0]] – PhSerRS + Ser-SA<br />
Line 669: Line 688:
**[[2cja]] – MbSerRS + ATP<br />
**[[2cja]] – MbSerRS + ATP<br />
**[[1ses]], [[1set]] – TtSerRS + Ser-adenylate analog<br />
**[[1ses]], [[1set]] – TtSerRS + Ser-adenylate analog<br />
 +
**[[6r1m]], [[6r1n]] – SaSerRS + Ser-SA<br />
 +
**[[6hdz]], [[6he1]], [[6hhy]], [[6hi0]] – PaSerRS + Ser-SU<br />
 +
**[[6he3]], [[6hhz]] – PaSerRS + Ser-SC<br />
 +
**[[6r1o]] – EcSerRS + Ser-SA<br />
 +
**[[6h9x]] – KpSerRS + Ser-SA<br />
 +
**[[7ap1]] – KpSerRS + inhibitor<br />
 +
**[[6ote]] – CpSerRS + Ser-SA<br />
 +
**[[6x94]] – MmSerRS + Ser-SA<br />
* ''Ser-RS + tRNA''
* ''Ser-RS + tRNA''
Line 681: Line 708:
**[[2du3]], [[5x6c]] – AfPSerRS + Cys-tRNA + phosphoserine<br />
**[[2du3]], [[5x6c]] – AfPSerRS + Cys-tRNA + phosphoserine<br />
**[[2du5]], [[2du6]] - AfPSerRS (mutant) + Cys-tRNA + phosphoserine<br />
**[[2du5]], [[2du6]] - AfPSerRS (mutant) + Cys-tRNA + phosphoserine<br />
 +
**[[2odr]] - MemPSerRS <br />
*'''Thr-RS'''
*'''Thr-RS'''
Line 686: Line 714:
**[[1wwt]] – hThrRS TGS domain – NMR<br />
**[[1wwt]] – hThrRS TGS domain – NMR<br />
**[[3ugq]], [[3ugt]] - yThrRS <br />
**[[3ugq]], [[3ugt]] - yThrRS <br />
-
**[[1y2q]] - PaThrRS editing domain<br />
+
**[[1y2q]] - PabThrRS editing domain 1-143<br />
-
**[[1tje]] - EcThrRS editing domain<br />
+
**[[1tje]] - EcThrRS editing domain 1-224<br />
 +
**[[7l3o]] - CpThrRS <br />
* ''Thr-RS + small substrates or analogs''
* ''Thr-RS + small substrates or analogs''
-
**[[4p3n]] - hThrRS editing domain + borrelidin<br />
+
**[[4p3n]] - hThrRS editing domain 322-723 + borrelidin<br />
**[[4hws]] - hThrRS editing domain + inhibitor<br />
**[[4hws]] - hThrRS editing domain + inhibitor<br />
**[[3uh0]] - yThrRS editing domain + Thr-SA<br />
**[[3uh0]] - yThrRS editing domain + Thr-SA<br />
**[[4eo4]] - yThrRS editing domain + Ser-SA<br />
**[[4eo4]] - yThrRS editing domain + Ser-SA<br />
-
**[[3pd2]], [[3pd3]], [[3pd4]], [[3pd5]] – PaThrRS editing domain + aa-aminoadenosine<br />
+
**[[3pd2]], [[3pd3]], [[3pd4]], [[3pd5]] – PabThrRS editing domain + aa-aminoadenosine<br />
-
**[[2hkz]] – PaThrRS editing domain + Ser<br />
+
**[[2hkz]] – PabThrRS editing domain + Ser<br />
-
**[[2hl0]], [[2hl1]] - PaThrRS editing domain + Ser-adenylate<br />
+
**[[2hl0]], [[2hl1]] - PabThrRS editing domain + Ser-adenylate<br />
-
**[[2hl2]] - PaThrRS editing domain + Ser-SA<br />
+
**[[2hl2]] - PabThrRS editing domain + Ser-SA<br />
**[[1tke]] - EcThrRS editing domain + Ser<br />
**[[1tke]] - EcThrRS editing domain + Ser<br />
**[[1tkg]] - EcThrRS editing domain + Ser-SA<br />
**[[1tkg]] - EcThrRS editing domain + Ser-SA<br />
Line 712: Line 741:
**[[4rrf]] - MjThrRS editing domain + Ser<br />
**[[4rrf]] - MjThrRS editing domain + Ser<br />
**[[4rrg]] - MjThrRS editing domain + Thr<br />
**[[4rrg]] - MjThrRS editing domain + Thr<br />
 +
**[[6l2q]] - ThrRS 222-622 + inhibitor – ''Salmonella enterica''<br />
* ''Thr-RS + tRNA''
* ''Thr-RS + tRNA''
Line 719: Line 749:
**[[1kog]] – EcThrRS catalytic and anticodon-binding domains + mRNA<br />
**[[1kog]] – EcThrRS catalytic and anticodon-binding domains + mRNA<br />
-
*'''Multifunctional RS'''
 
- 
-
**[[1fyj]] – hRS – NMR<br />
 
}}
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Revision as of 09:42, 16 March 2021

3D Structures of Aminoacyl tRNA Synthetase

Updated on 16-March-2021

{{#tree:id=OrganizedByTopic|openlevels=0|

  • Class I aaRS
  • Arg-RS
    • 4zaj - hArgRS – human
    • 4q2y – hArgRS (mutant)
    • 1bs2 – yArgRS - yeast
    • 3gdz – KpArgRS residues 1-106 – Klebsiella pneumoniae
    • 1iq0 – TtArgRS - Thermus thermophilus
  • Arg-RS + small substrates or analogs
    • 4q2t – hArgRS (mutant) + Arg
    • 4q2x – hArgRS (mutant) + canavanine
    • 6ao8 - NgArgRS + Arg – Neisseria gonorrhoeae
    • 5yym, 4oby - EcArgRS + Arg – Escherichia coli
  • Arg-RS + tRNA
    • 2zuf - PhArgRS + tRNA-Arg - Pyrococcus horikoshii
    • 1f7v - yArgRS + Arg-tRNA
    • 5yyn, 5b63 - EcArgRS + Arg-tRNA
  • Arg-RS ternary complex
    • 4z3z - hArgRS + GlnRS + AIMP1
    • 1f7u – yArgRS + Arg-tRNA + Arg
    • 2zue – PhArgRS + tRNA-Arg + ATP analog
  • Cys-RS
    • 1li5 - EcCysRS
    • 1li7 - EcCysRS + Cys
    • 1u0b – EcCysRS + Cys-tRNA
    • 3tqo – CysRS – Coxiella burnetii
    • 3sp1 - BbCysRS – Borrelia burgdorferi
    • 3c8z – MsCysRS + Cys-SA - Mycobacterium smegmatis
    • 6ujd - ElCysRS (mutant) – Elizabethkingia
  • Gln-RS
    • 4ye6 – hGlnRS
    • 4ye8, 4ye9 – hGlnRS (mutant)
    • 4h3s – yGlnRS
    • 3tl4 – yGlnRS tRNA-binding domain
    • 1nyl – EcGlnRS
    • 5zdo – TtGlnRS
    • 5zdk, 5zdl – TtGlnRS + ATP
    • 2gls, 1lgr – StGlnRS – Salmonella typhimurium
    • 5bnz – PaGlnRS – Pseudomonas aeruginosa
    • 4p2b – TgGlnRS catalytic domain – Toxoplasma gondii
    • 2lgs – StGlnRS + Glu<br /
    • 1qrs, 1qrt, 1qru - EcGlnRS (mutant) + Gln-tRNA
    • 1gtr, 1gts, 1gsg - EcGlnRS + Gln-tRNA
  • Gln-RS ternary complex
    • 1euq, 1euy – EcGlnRS + Gln-tRNA + Gln-SA
    • 1exd - EcGlnRS + Gln-tRNA (mutant) + AMP
    • 4jxx, 4jxz, 4jyz - EcGlnRS + Gln-tRNA + ATP
    • 1qtq - EcGlnRS + Gln-tRNA + Gln analog
  • Glu-RS
    • 2hra – yGluRS N-terminal
    • 1gln – TtGluRS
    • 2o5r - TmGluRS
    • 3aii – GluRS – Methanothermobacter thermautotrophicus
    • 2ja2, 3pny – MtGluRS – Mycobacterium tuberculosis
    • 3pnv - MtGluRS (mutant)
    • 4a91 – EcGluRS
    • 2hz7 – DrGluRS – Deinococcus radiodurans
    • 6b1p - HpGluRS – Helicobacter pylori
    • 6b1z - EaGluRS – Elizabethkingia anophelis
    • 5tgt – PaGluRS
    • 5h4v – GluRS – Xanthomonas oryzae
    • 7k86 – SmGluRS – Stenotrophomonas maltophilia
  • Glu-RS + small substrates or analogs
    • 3afh - TmGluRS + Glu-AMP analog
    • 2rd2, 2re8 – EcGluRS (mutant) + Glu-SA
    • 2cuz – TtGluRS + Glu
    • 1j09 - TtGluRS + Glu + ATP
    • 1n75 - TtGluRS + ATP
    • 2cfo - GluRS residues 2-485 + Glu – Synechococcus elongatus
    • 6brl - GluRS + Glu - Elizabethkingia meningoseptica
    • 4grl - BbGluRS + Glu
    • 4g6z - BtGluRS + Glu – Burkholderia thailandensis
  • Glu-RS + tRNA
    • 1zjw – EcGluRS + Glu-tRNA
    • 1g59 – TtGluRS + Glu-tRNA
  • Glu-RS ternary complex
    • 5bmu – hGluRS GST-like domain + EPRS-AIMP3
    • 2hrk, 2hsm - yGluRS N-terminal + GU4 nucleic-binding protein 1
    • 3akz, 3al0 – TmGluRS + tRNA + Glu-AMP analog – Thermotoga maritima
    • 1o0b, 1o0c - EcGluRS + Glu-tRNA + Glu + AMP
    • 2cv0, 1n77 - TtGluRS + Glu + Glu-tRNA
    • 1n78 - TtGluRS + Glu-ol + Glu-tRNA
    • 2cv1 - TtGluRS + Glu-ol + ATP + Glu-tRNA
    • 2cv2 - TtGluRS + Glu-SA + Glu-tRNA
  • Ile-RS
    • 1ile - TtIleRS
    • 1wny, 1udz – TtIleRS editing domain 201-381
  • Ile-RS + small substrates or analogs
    • 1ue0 - TtIleRS editing domain + Val
    • 1wnz - TtIleS editing domain + Val-adenylate
    • 1wk8 - TtIleRS editing domain + Val-SA
    • 1jzq – TtIleS + Ile-adenylate analog
    • 1jzs – TtIleS + antibiotic
  • Ile-RS ternary complex
    • 1ffy, 1qu2, 1qu3 - SaIleRS + Ile-tRNA + antibiotic - Staphylococcus aureus
    • 6ldk - CaIleRS + AMP + Ile – Candida albicans
  • Leu-RS
    • 2wfd – hLeuRS editing domain 260-509
    • 3o0a, 3pz0 – AaLeuRS hydrolytic domain – Aquifex aeolicus
    • 3pz5 – AaLeuRS hydrolytic domain (mutant)
    • 2wfe - CaLeuRS editing domain – Candida albicans
    • 5agh - CaLeuRS editing domain (mutant)
    • 2ajg - EcLeuRS editing domain
    • 1wkb – PhLeuRS residues 1-810
    • 5fon - CmLeuRS editing domain – Cryptosporidium muris
    • 5foc - PfLeuRS editing domain
    • 5fod - PfLeuRS editing domain (mutant)
    • 5fof - LeuRS editing domain – Plasmodium knowlesi
    • 4k48 - SpLeuRS editing domain (mutant) – Streptococcus pneumoniae
    • 3pz6 - LeuRS editing domain (mutant) – Giardia intestinalis
  • Leu-RS + small substrates or analogs
    • 6kqy - hLeuRS + Leu
    • 7d5c - yLeuRS + inhibitor
    • 6ykk, 6ykl, 6ykn, 6yko, 6ykq, 6yks, 6ykt, 6yku, 6ykv, 6kyw, 6ykx, 7a0p, 7ap2 - NgLeuRS (mutant) + inhibitor
    • 6q89, 6q8a, 6q8b, 6q8c - NgLeuRS (mutant) + intermediate analog
    • 2wfg - CaLeuRS editing domain + benzoxaborole-AMP
    • 1h3n - TtLeuRS + Leu-SA
    • 1obc, 1obh – TtLeuRS + substrate analog
    • 2ajh, 2aji - EcLeuRS editing domain + aa
    • 4aq7 - EcLeuRS editing domain + Leu-adenylate analog
    • 4cqn - EcLeuRS editing domain + Ile-adenylate analog
    • 5fog - CmLeuRS editing domain + norvaline
    • 5fol - CmLeuRS editing domain + Ile
    • 5fom - CmLeuRS editing domain + inhibitor
    • 5agj - CaLeuRS editing domain + AMP derivative
    • 5agi - CaLeuRS editing domain (mutant) + AMP derivative
    • 5agr, 5ags, 5agt - MtLeuRS editing domain + inhibitor
    • 7bzj - SpLeuRS + inhibitor
    • 4k47 - SpLeuRS editing domain (mutant) + benzoxaborole-AMP
    • 3ziu - LeuRS editing domain + Leu-SA – Mycoplasma mobile
  • Leu-RS + tRNA
    • 1wz2 – PhLeuRS + Leu-tRNA
    • 5ah5 - LeuRS + Leu-tRNA – Agrobacterium radiobacter
  • Leu-RS ternary complex
    • 6kie, 6kr7 - hLeuRS + Leu-SA + Leu
    • 6lpf, 6lr6 - hLeuRS + Leu-SA + adenosine derivative
    • 6kid - hLeuRS + ATP + Leu
    • 4arc - EcLeuRS + Leu-tRNA + Leu
    • 5omw - EcLeuRS + Leu-tRNA + Leu-adenylate analog
    • 4ari, 4as1, 3zjt, 3zju, 3zjv - EcLeuRS + Leu-tRNA + benzoxaborole
    • 3zgz - EcLeuRS + Leu-tRNA + inhibitor
    • 5onh - EcLeuRS + Leu-tRNA + Leu-adenylate analog + norvaline
    • 5on2 - EcLeuRS (mutant) + Leu-tRNA + Leu-adenylate analog + norvaline
    • 5on3 - EcLeuRS (mutant) + Leu-tRNA + Leu-adenylate analog + Leu
    • 2v0g - TtLeuRS + Leu-tRNA + benzoxaborole-AMP
    • 2bte, 2byt - TtLeuRS + Leu-tRNA + Leu
    • 2v0c – TtLeuRS + Leu-SA + benzoxaborole-AMP
  • Lys-RS
    • 3bju – hLysRS residues 70-579
    • 6ilh - hLysRS (mutant)
    • 1irx – PhLysRS
    • 1bbw – EcLysRS
    • 5yzx - EcLysRS (mutant)
    • 1krs, 1krt – EcLysRS anticodon-binding domain – NMR
    • 3dsq – DhLysRS – Desulfitobacterium hafniense
    • 4up8 - EhLysRS – Entamoeba histolytica
    • 4h02 - PfLysRS – Plasmodium falciparum
  • Lys-RS binary complexes
    • 6chd - hLysRS + Lys-adenylate derivative
    • 4up7 - EhLysRS + Lys-adenylate
    • 4up9 - EhLysRS + ATP
    • 4upa - EhLysRS (mutant) + AMPPNP
    • 3e9h, 3e9i]] – BsLysRS + Lys-SA - Bacillus stearothermophilus
    • 3a74 - BsLysRS + diadenosine tetraphosphate
    • 5zh2, 5zh3, 5zh4, 5zh5, 4pg3, 6hcv - PfLysRS + inhibitor
    • 4ycv - PfLysRS + cladosporin
    • 5vl1 - MuLysRS + Lys – Mycobacterium ulcerans
    • 5hgq - LysRS + cladosporin – eye worm
    • 1bbu, 1e1o, 1lyl – EcLysRS + Lys
    • 1e1t - EcLysRS + Lys-adenylate
    • 6c86 - CpLysRS + Lys-adenylate derivative - Cryptosporidium parvum
    • 5eln - CpLysRS + Lys
    • 4ex5 - BtLysRS + Lys
    • 6wbd - SmLysRS + Lys
  • Lys-RS ternary complexes
    • 6ild, 4dpg - hLysRS + P38 + AIMP2
    • 4ycu - hLysRS + P38 + cladosporin
    • 4ycw - hLysRS (mutant) + P38 + cladosporin
    • 1e22 - EcLysRS + Lys + AMPPCP
    • 1e24 - EcLysRS + Lys + ATP
    • 6nrz - CtLysRS + Lys + adenosine – Chlamydia trachomatis
    • 6ns0, 6o3f - CtLysRS + Lys + cladosporin
    • 6bni - CpLysRS + Lys + adenine
    • 5elo - CpLysRS + Lys + cladosporin
    • 6aqg - MuLysRS + Lys + cladosporin
    • 6agt, 6ka6, 6kab, 6kbf, 6kcn, 6kct - PfLysRS + Lys + cladosporin derivative
    • 7bt5 - PfLysRS + Lys + drug
    • 6hcu, 6hcw - PfLysRS + Lys + inhibitor
    • 6aqh - LysRS + Lys + cladosporin – Mycobacterium thermoresistibile
  • Met-RS
    • 5gl7 – hMetRS residues 221-834
    • 2djv – hMetRS WHEP-TRS domain 835-900 – NMR
    • 1med, 1mea – EcMetRS Zinc-binding domain - NMR
    • 1qqt, 3h9c - EcMetRS residues 2-552
    • 3h97, 6spp – EcMetRS residues 2-548 (mutant)
    • 1a8h – TtMetRS
    • 2d54, 2d5b – TtMetRS (mutant)
    • 1woy – TtMetRS residues 1-500 (mutant)
    • 1pyb – AaMetRS subunit
    • 1rqg – PabMetRS – Pyrococcus abyssi
    • 1mkh – PabMetRS C-terminal
    • 5xgq – MtMetRS
    • 5h34 – MetRS C-terminal – Nanoarchaeum equitans
    • 2x1l - MsMetRS residues 2-515
  • Met-RS + small substrates or analogs
    • 5goy – hMetRS residues 221-834 + Met
    • 3kfl – LmMetRS residues 206-747+ Met-adenylate - Leishmania major
    • 2x1m - MsMetRS residues 2-515 + Met
    • 1p7p, 1pfu, 1pfv, 1pfw - EcMetRS residues 2-548 + Met
    • 1pfy - EcMetRS residues 1-551 + Met-SA
    • 1f4l, 6spo - EcMetRS residues 1-551 + Met
    • 6spq - EcMetRS (mutant) + Met
    • 6spn - EcMetRS + beta-Met
    • 6spr - EcMetRS (mutant) + beta-Met
    • 1pg0 - EcMetRS residues 1-551 + Met-adenylate
    • 1pg2 - EcMetRS residues 1-551 + Met + adenine
    • 3h99 - EcMetRS residues 2-548 (mutant) + Met
    • 3h9b - EcMetRS residues 2-548 (mutant) + azidonorleucine
    • 4dlp - BmMetRS + SMet – Brucella melitensis
    • 4py2 – BmMetRS + inhibitor
    • 6ax8, 5xet – MtMetRS + Met-adenylate
    • 3vu8 – TtMetRS + Met-adenylate analog
    • 5urb - AbMetRS + Met – Acinetobacter baumannii
    • 5k0s, 5k0t – MetRS + inhibitor – Brucella suis
    • 4zt2, 4zt3, 4zt4, 4zt5, 4zt6, 4zt7, 4mvw, 4mvx, 4mvy, 4mw0, 4mw1, 4mw2, 4mw4, 4mw5, 4mw6, 4mw7, 4mw9, 4mwb, 4mwc, 4mwd, 4mwe - TbMetRS residues 237-773 (mutant) + inhibitor – Trypanosoma brucei
    • 6cml, 6mes - TbMetRS residues 237-773 (mutant) + Met + inhibitor
    • 4qrd, 4qre - SaMetRS + antibacterial
  • Met-RS + tRNA
    • 2csx – AaMetRS + Met-tRNA
    • 2ct8 - AaMetRS + Met-tRNA + Met-SA
    • 2dxi – TtMetRS + tRNA + ATP + Glu-ol
  • Met-RS + protein
    • 4bl7, 4bvx, 4bvy - hMetRS N-terminal + elongation factor P18
    • 2hsn - yMetRS N-terminal + GU4 nucleic-binding protein 1 N-terminal
  • Trp-RS
    • 1o5t, 1ulh – hTrpRS catalytic fragment
    • 5uji – hTrpRS catalytic fragment (mutant)
    • 3kt0, 2ip1 – yTrpRS
    • 1d2r - BsTrpRS
    • 3prh – TrpRS (mutant) – Bacillus subtilis
    • 3n9i – TrpRS – Yersinia pestis
    • 3m5w – CjTrpRS – Campylobacter jejuni
    • 3a04 – ApTrpRS – Aeropyrum pernix
    • 3hzr – EhTrpRS
    • 3i05 – TbTrpRS residues 3-389
    • 3hv0 – CpTrpRS residues 206-593
    • 3foc – GlTrpRS – Giardia lamblia
    • 2el7 – TtTrpRS
    • 2yy5 – TrpRS – Mycoplasma pneumoniae
    • 2g36 – TmTrpRS
    • 6mtk - EaTrpRS
    • 5tev - NgTrpRS
    • 4j76 - PfTrpRS
  • Trp-RS + small substrates or analogs
    • 5ujj – hTrpRS + Trp-AMP
    • 2quh – hTrpRS + Trp
    • 2qui - hTrpRS + Trp-amide + ATP
    • 2quj - hTrpRS + Trp-adenylate
    • 2quk – hTrpRS + ATP
    • 3kt3 – yTrpRS + Trp-adenylate
    • 3kt6, 3kt8 – yTrpRS + Trp
    • 3a05 – ApTrpRS + Trp
    • 3jxe – PhTrpRS + Trp-adenylate
    • 2ov4 – BsTrpRS + adenosine tetraphosphate
    • 1i6k, 1i6l, 1i6m – BsTrpRS + Trp-adenylate
    • 1yid, 2a4m – DrTrpRS + ATP
    • 1yi8, 1yia– DrTrpRS + Trp
    • 1maw, 1m83 - BsTrpRS + ATP
    • 1mb2 - BsTrpRS + Trp
    • 1bks – StTrpRS + pyridoxal phosphate
    • 6ncr - CtTrpRS + Trp
    • 5tew - NgTrpRS + Trp
    • 4j75 - PfTrpRS + Trp-AMP
    • 6dfu - TrpRS + Trp – Haemophilus influenzae
  • Trp-RS ternary complex
    • 5ekd – hTrpRS + ATP + indolmycin
    • 5dk4 – BsTrpRS + ATP + indolmycin
    • 3fhj, 3ghd, 3fi0 – BsTrpRS + Trp + AMP + Pi
    • 1mau – BsTrpRS + Trp + ATP
    • 5v0i - EcTrpRS + Trp + AMP
  • Trp-RS + tRNA
    • 2ake, 2dr2 - hTrpRS + Trp-tRNA
    • 2azx – hTrpRS (mutant) + tRNA
  • Tyr-RS
  • Tyr-RS + small substrates or analogs
    • 1q11 – hTyrRS residues 1-364 + Tyr-ol
    • 2pid – hTyrRS residues 28-375 + Tyr-SA
    • 4q93 - hTyrRS + resveratrol
    • 4qbt - hTyrRS + Tyr
    • 3zxi - hTyrRS + Tyr-adenylate analog
    • 3ts1 – BsTyrRS + Tyr-adenylate intermediate
    • 4ts1 – BsTyrRS + Tyr
    • 3p0h, 3p0i]], 3p0j]] – LmTyrRS + inhibitor
    • 3n2y – MjTyrRS + tetrazolyl phenylalanine
    • 2zp1 – MjTyrRS (mutant) + Tyr
    • 1zh0 - MjTyrRS (mutant) + naphthyl-Ala
    • 1zh6, 2ag6, 4pbr - MjTyrRS (mutant) + Phe derivative
    • 4hjx - MjTyrRS (mutant) + di-fluoro-Tyr
    • 4nx2 - MjTyrRS (mutant) + di-chloro-Tyr
    • 4hpw - MjTyrRS (mutant) + methyl-Tyr
    • 5n5u - MjTyrRS + borono-Phe + AMP
    • 2yxn – EcTyrRS residues 1-322 + azido-Tyr
    • 1vbm – EcTyrRS + Tyr-SA
    • 1vbn – EcTyrRS (mutant) + Tyr-SA
    • 1x8x – EcTyrRS + Tyr
    • 1wq3, 1wq4 - EcTyrRS (mutant) + Tyr
    • 6wn2, 6wrn, 6wrt - EcTyrRS (mutant) + Tyr derivative
    • 4oud - EcTyrRS + bi-Phe
    • 6i5y - EcTyrRS + Tyr-SA
    • 6hb5 - EcTyrRS + Tyr-SC
    • 6hb6, 6hb7 - EcTyrRS + Tyr-SU
    • 7ap3 - EcTyrRS + inhibitor
    • 2j5b – TyrRS residues 2-346 + Tyr-ol – Acanthamoeba polyphaga minivirus
    • 2cyb – AfTyrRS + Tyr - Archaeoglobus fulgidus
    • 2cyc – PhTyrRS + Tyr
    • 1h3f- TtTyrRS + Tyr-ol
    • 1jii, 1jij, 1jil, 1jik – SaTyrRS + inhibitor
    • 6otj – NgTyrRS + Tyr
  • Tyr-RS + tRNA
    • 2dlc – yTyrRS + tRNA + Tyr-SA
    • 1j1u – MjTyrRS + Tyr-tRNA
    • 1h3e - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP
    • 2rkj – NcTyrRS + RNA
  • 3-nitroTyr-RS
    • 4nd6, 4nd7 - MjNTyrRS (mutant)
    • 4nda - MjNTyrRS (mutant) + nitro-Tyr
  • Val-RS
    • 4xkz - hLysRS C-terminal
    • 1iyw - TtValRS
    • 1wk9, 1wka – TtValRS CP1 domain
    • 1ivs – TtValRS + Val-SA + Val-tRNA
    • 1gax - TtValRS + Val-adenylate analog + Val-tRNA
  • Class II aaRS
  • Ala-RS
  • Ala-RS + small substrates or analogs
    • 5v59 - hAlaRS + AZ-SA
    • 3hxu, 3hxv, 3hxw – EcAlaRS catalytic fragment + aa-adenylate
    • 3hxz, 3hy0, 3hy1 - EcAlaRS catalytic fragment (mutant) + aa-adenylate
    • 3hxx - EcAlaRS catalytic fragment + AMPPCP
    • 3hxy - EcAlaRS catalytic fragment + AMPPCP + Ala-AMP + PCP
    • 3htz - AaAlaRS residues 2-454 + Ser
    • 1yfr – AaAlaRS + ATP
    • 1yfs – AaAlaRS + Ala
    • 1yft, 1ygb - AaAlaRS catalytic fragment + aa
    • 2zzg - PhAlaRS + Ala-SA
    • 2ztg– AfAlaRS + Ala-SA
  • Ala-RS + tRNA
    • 3wqy, 3wqz – AfAlaRS + Ala-tRNA + Ala-SA
  • Asp-RS
  • Asp-RS + small substrates or analogs
    • 3nel – TkAspRS + Asp
    • 3nem - TkAspRS + Asp-adenylate
    • 5w25 – MtAspRS + Asp
    • 4o2d – MsAspRS + Asp
  • Asp-RS + tRNA
  • Asp-RS complex
    • 5y6l - hAspRS + MetRS + Glu/ProRS + P18 + P38
    • 6iy6 - hAspRS + AIMP2 + Glu/ProRS residues 1-157
    • 1il2, 1c0a – EcAspRS + Asp-tRNA + Asp-adenylate
    • 7ap4 – TtAspRS + inhibitor
    • 6hhv, 6hhw – TtAspRS + Asp-SU
    • 6hhx – TtAspRS + Asp-SC
    • 6sjc – TtAspRS + Asp-SA
    • 4wj4 – PaAspRS + Asn-tRNA + Asp
    • 4wj3 – PaAspRS + Asn-tRNA + amidotransferase
  • Asn-RS
    • 5xix - hAsnRS
    • 4zya - hAsnRS N terminal
    • 1x56 - PhAsnRS
    • 2kqr – BmAsnRS N-terminal – NMR – Brugia malayi
    • 6pqh – ElAsnRS
  • Asn-RS + small substrates or analogs
    • 2xti – BmAsnRS catalytic fragment + Asn-adenine analog
    • 2xgt - BmAsnRS catalytic fragment + Asn-SA
    • 1x54 – PhAsnRS + Asn-adenylate
    • 1x55 - PhAsnRS + Asn-SA
    • 11as – EcAsnRS + Asn
    • 12as - EcAsnRS + Asn + AMP
    • 3rl6 - PaAsnRS + Asn + AMP
  • Gly-RS
    • 2q5h – hGlyRS residues 55-739
    • 2q5i, 4kqe - hGlyRS residues 55-739 (mutant)
    • 2pme – hGlyRS
    • 2pmf – hGlyRS (mutant)
    • 1j5w – TmGlyRS chain
    • 1ati – TtGlyRS
    • 3rf1 - CjGlyRS a subunit
  • Gly-RS + small substrates or analogs
    • 2zt5, 2zxf – hGlyRS residues 55-739 + bis-adenosine tetraphosphate
    • 2zt6 - hGlyRS residues 55-739 + AMPCPP
    • 2zt7 - hGlyRS residues 55-739 + Gly + ATP
    • 2zt8 - hGlyRS residues 55-739 + Gly-AMP analog
    • 1b76 – TtGlyRS + ATP
    • 1ggm – TtGlyRS + Gly-adenylate
    • 5f5w - AaGlyRS + Gly-adenylate
    • 3ufg - CjGlyRS + ATP
  • Gly-RS + tRNA
  • His-RS
  • His-RS + small substrates or analogs
    • 4phc - hHisRS + His
    • 3lc0 – TcHisRS residues 45-478 + His – Trypanosoma cruzi
    • 4yp0, 4ypf, 4yrc, 4yrr, 4yrs - TcHisRS + quinoline derivative
    • 4yre, 4yrj, 4yrk, 4yrp - TcHisRS + phenyl derivative
    • 4yrg, 4yrm, 4yrn, 4yro - TcHisRS + pyridine derivative
    • 4yrl - TcHisRS + aniline derivative
    • 4yrq - TcHisRS + chromenone derivative
    • 4yrt - TcHisRS + naphthalene derivative
    • 4rdx – TtHisRS + tRNA
    • 1adj – TtHisRS + His
    • 3hrk - TbHisRS + His-adenylate
    • 2el9 - EcHisRS + His-SA
    • 1kmm, 1ady]] - EcHisRS + His-adenylate
    • 1kmn - EcHisRS + His-ol + ATP
    • 5e3i - AbHisRS + His + ATP
    • 4e51 - BtHisRS + His
  • Phe-RS
    • 3l4g, 3cmq – hPheRS
    • 5mgw, 5mgh, 5mgu, 5mgv – hPheRS (mutant)
    • 1pys – TtPheRS
    • 2cxi – PhPheRS β chain N-terminal
    • 3ica – PheRS β chain – Porphyromonas gingivalis
    • 4p71 – PaPheRS α+β chain
    • 3ig2 – PheRS β chain – Bacterioides fragilis
    • 7daw – MtPheRS + α+β chains
    • 6p24 – EcPheRS + α+β chains
  • Phe-RS + small substrates or analogs
    • 3hfv – hPheRS + Tyr
    • 3teg – hPheRS + L-DOPA
    • 3pco – EcPheRS + phenylalanine+ AMP
    • 6oz5, 6p26 – EcPheRS α+β chains + inhibitor
    • 3hfz, 2amc – TtPheRS α+β chains + Tyr
    • 2akw, 1b70 - TtPheRS α+β chains + Phe
    • 4tva - TtPheRS α+β chains + Phe + puromycin
    • 3teh - TtPheRS α+β chains + L-DOPA
    • 1jjc, 1b7y - TtPheRS α+β chains + Phe-adenylate
    • 2aly - TtPheRS α+β chains + Phe-SA
    • 2rhq, 2rhs – PheRS α+β+ chains (mutant) + inhibitor – Staphylococcus haemolyticus
    • 4p72, 4p73, 4p74, 4p75 – PaPheRS α+β chains + inhibitor
    • 7db7, 7db8 – MtPheRS α+β chains + inhibitor
    • 6p8t – AbPheRS α+β chains + inhibitor
  • Phe-RS + tRNA
    • 3tup – hPheRS + Phe-tRNA
    • 1eiy - TtPheRS α+β chains + Phe-tRNA
    • 2iy5 - TtPheRS α+β chains + Phe-ol + Phe-tRNA
  • Pro-RS
    • 4k86 – hProRS residues 1000-1512
    • 1hc7 – TtProRS
    • 2i4l – RpProRS – Rhodopseudomonas palustris
    • 1nj2 - MtProRS – Methanothermobacter thermautotrophicus
    • 1nj8 – MjProRS
    • 5xif, 6aa0 – TgProRS residues 334-830
    • 5ucm – PaProRS
    • 4twa, 4ncx – PfProRS residues 249-746
  • Pro-RS + small substrates or analogs
    • 3ial – GlProRS residues 34-542 + Pro-adenylate
    • 2i4m, 2i4n – RpProRS + aa-SA
    • 2i4o – RpProRS + ATP
    • 2j3l – EfProRS + Pro-SA – Enterococcus faecalis
    • 1nj1, 1nj5, 1nj6 – MtProRS + aa-SA
    • 1h4t - TtProRS + Pro
    • 5ifu – PfProRS residues 249-746 + glyburide
    • 4wi1 – PfProRS residues 249-746 + inhibitor
  • Pro-RS ternary complex
    • 4k87 – hProRS residues 1000-1512 + proline + adenosine
    • 4k88 – hProRS residues 1000-1512 + halofunginone
    • 1h4q - TtProRS + Pro-tRNA + Pro-ol
    • 1h4s - TtProRS + Pro-tRNA + Pro-SA
    • 2j3m – EfProRS + Pro-ol + ATP
    • 5f9z – CpProRS residues 186-688 + halofuginone + AMPPNP
    • 5f9y – CpProRS residues 186-688 + proline + AMP
    • 5xio – CpProRS residues 225-719 + halofuginone + ANP
    • 5znj – SaProRS + halofuginone + ANP
    • 5znk – SaProRS + inhibitor + ANP
    • 6nab - NfProRS + Pro + AMP – Naegleria fowleri
    • 6uyh – NfProRS + halofuginone + ANP
    • 5xiq – TgProRS residues 334-830 + halofuginone + ANP
    • 5xik, 6a88 – TgProRS residues 334-830 + febrifugine derivative + ANP
    • 5xig, 5xih, 5xij – TgProRS residues 334-830 + inhibitor + ANP
    • 5xii – TgProRS residues 334-830 (mutant) + inhibitor + ANP
    • 4ydq, 4q15, 4olf – PfProRS residues 254-746 + halofuginone + AMPPNP
    • 6t7k – PfProRS residues 254-746 + inhibitor
  • Bifunctional RS (bifunctional glutamate/proline tRNA ligase)
    • 4hvc – hGlu/ProRS residues 1003-1513 + halofunginone + ATP analog
    • 5v58 – hGlu/ProRS residues 1003-1513 + AZ-SA
    • 5vad – hGlu/ProRS residues 1003-1513 + inhibitor
    • 5a1n, 5a34, 5a5h – hGlu/ProRS GST-like domain + EPRS-AIMP2
    • 1fyj – hGlu/ProRS 677-733 – NMR
      , [[6
  • Pyrrolysyl-RS; domains – RNA-binding 1-101; catalytic 188-454
    • 2e3c - MmPylRS catalytic domain - Methanosarcina mazei
    • 3vqw, 3vqx, 4cs2 - MmPylRS catalytic domain (mutant)
    • 3dsq – DhPylRS
    • 6ezd, 6jp2 – PylRS – Methanomethylophilus alvus
  • Pyrrolysyl-RS binary complex
    • 3qtc – MmPylRS catalytic domain (mutant) + AMP-ATP analog
    • 2q7e - MmPylRS catalytic domain + ATP analog
    • 3vqv - MmPylRS catalytic domain + AMPPNP
    • 4bw9, 4cs4, 5k1p, 5k1x - MmPylRS catalytic domain (mutant) + AMPPNP
    • 4bwa - MmPylRS catalytic domain (mutant) + adenylated norbornene
    • 4ch3, 4ch4, 4ch5, 4ch6 - MmPylRS catalytic domain + adenylated lysine derivative
    • 4cs3 - MmPylRS catalytic domain (mutant) + adenylated lysine derivative
    • 5ud5 - MmPylRS RNA-binding domain + Pyl-RNA
    • 5v6x - MmPylRS RNA-binding domain (mutant) + Pyl-RNA
    • 2zni, 2znj – DhLysRS + tRNA
  • Pyrrolysyl-RS ternary complex
    • 2zce - MmPylRS catalytic domain + pyrrolysine + ATP analog
    • 2q7g - MmPylRS catalytic domain + pyrrolysine analog + ATP
    • 2zim, 2q7h - MmPylRS catalytic domain + adenylated pyrrolysine + pyrophosphate
    • 2zio - MmPylRS catalytic domain + AlocLys-AMP + ATP analog
    • 3vqy - MmPylRS catalytic domain + butoxycarbonyl lysine + AMPPNP
    • 4q6g - MmPylRS catalytic domain + acetyl lysine + ADPNP
    • 4tqd - MmPylRS catalytic domain + iodo-Phe + ATP
    • 4tqf, 4zib - MmPylRS catalytic domain + bromothienylo-Ala + ATP
    • 6ly3, 6ly6, 6lyb - MmPylRS catalytic domain (mutant) + Ala derivative+ ANP
    • 6ly7, 6lya - MmPylRS catalytic domain (mutant) + Trp derivative + ANP
    • 2zin - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog
    • 6aac, 6aad, 6aao, 6aap, 6aaz, 6ab0, 6ab1, 6ab2, 6ab8, 6abk, 6abl, 6abm, 6aan, 6anq - MmPylRS catalytic domain + azanyl derivative + ATP
  • Ser-RS
    • 3vbb - hSerRS
    • 6gir - SerRS – Arabidopsis thaliana
    • 3lsq – TbSerRS
    • 1sry - TtSerRS
    • 3lss – TbSerRS + ATP
    • 3err – TtSerRS/dynein heavy chain
    • 2zr3 – PhSerRS
    • 2dq3 – AaSerRS
    • 2du7 – MjSerRS
    • 2odr – MemSerRS – Methanococcus maripaludis
    • 2cim – MbSerRS – Methanosarcina barkeri
    • 3qne, 3qo5, 3qo7, 3qo8 - CaSerRS
  • Ser-RS + small substrates or analogs
    • 4l87 - hSerRS + Ser-SA
    • 1wle – bSerRS + Ser-adenylate - bovine
    • 2zr2 – PhSerRS + ATP
    • 2dq0 – PhSerRS + Ser-SA
    • 2cj9 – MbSerRS + Ser-SA
    • 2cjb – MbSerRS + Ser
    • 2cja – MbSerRS + ATP
    • 1ses, 1set – TtSerRS + Ser-adenylate analog
    • 6r1m, 6r1n – SaSerRS + Ser-SA
    • 6hdz, 6he1, 6hhy, 6hi0 – PaSerRS + Ser-SU
    • 6he3, 6hhz – PaSerRS + Ser-SC
    • 6r1o – EcSerRS + Ser-SA
    • 6h9x – KpSerRS + Ser-SA
    • 7ap1 – KpSerRS + inhibitor
    • 6ote – CpSerRS + Ser-SA
    • 6x94 – MmSerRS + Ser-SA
  • Ser-RS + tRNA
    • 4rqf - hSerRS + SeCys-tRNA
    • 4rqe - hSerRS (mutant) + SeCys-tRNA
    • 3w3s - SerRS (mutant) + SeCys-tRNA + Ser-SA – Methanopyrus kandleri
    • 1ser – TtSerRS + Ser-tRNA
  • PhosphoSer-RS
    • 2du4 - AfPSerRS + Cys-tRNA
    • 2du3, 5x6c – AfPSerRS + Cys-tRNA + phosphoserine
    • 2du5, 2du6 - AfPSerRS (mutant) + Cys-tRNA + phosphoserine
    • 2odr - MemPSerRS
  • Thr-RS
    • 1wwt – hThrRS TGS domain – NMR
    • 3ugq, 3ugt - yThrRS
    • 1y2q - PabThrRS editing domain 1-143
    • 1tje - EcThrRS editing domain 1-224
    • 7l3o - CpThrRS
  • Thr-RS + small substrates or analogs
    • 4p3n - hThrRS editing domain 322-723 + borrelidin
    • 4hws - hThrRS editing domain + inhibitor
    • 3uh0 - yThrRS editing domain + Thr-SA
    • 4eo4 - yThrRS editing domain + Ser-SA
    • 3pd2, 3pd3, 3pd4, 3pd5 – PabThrRS editing domain + aa-aminoadenosine
    • 2hkz – PabThrRS editing domain + Ser
    • 2hl0, 2hl1 - PabThrRS editing domain + Ser-adenylate
    • 2hl2 - PabThrRS editing domain + Ser-SA
    • 1tke - EcThrRS editing domain + Ser
    • 1tkg - EcThrRS editing domain + Ser-SA
    • 1tky - EcThrRS editing domain + Ser-adenylate
    • 4p3o, 4p3p - EcThrRS editing domain + borrelidin
    • 4hwo, 4hwp, 4hwr, 4hws - EcThrRS editing domain + inhibitor
    • 1fyf, 1evl - EcThrRS catalytic and anticodon-binding domains + aa-SA
    • 1evk - EcThrRS catalytic and anticodon-binding domains + Thr
    • 1nyq – SaThrRS + Thr-SA
    • 1nyr – SaThrRS + ATP
    • 4s02, 4s03, 4s0i, 4s0j, 4s0k, 4s0l - PabThrRS (mutant) + bi-Phe
    • 4rrq - PabThrRS editing domain + Ser
    • 4rrr - PabThrRS editing domain + Thr
    • 4rrf - MjThrRS editing domain + Ser
    • 4rrg - MjThrRS editing domain + Thr
    • 6l2q - ThrRS 222-622 + inhibitor – Salmonella enterica
  • Thr-RS + tRNA
    • 4yye - yThrRS + Thr-tRNA + Thr-SA
    • 1qf6 – EcThrRS + Thr-tRNA
    • 1kog – EcThrRS catalytic and anticodon-binding domains + mRNA

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Michal Harel, Joel L. Sussman

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