1dxe

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[[Image:1dxe.gif|left|200px]]
[[Image:1dxe.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1dxe |SIZE=350|CAPTION= <scene name='initialview01'>1dxe</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1dxe", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/2-dehydro-3-deoxyglucarate_aldolase 2-dehydro-3-deoxyglucarate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.20 4.1.2.20] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1dxe| PDB=1dxe | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxe OCA], [http://www.ebi.ac.uk/pdbsum/1dxe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dxe RCSB]</span>
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}}
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'''2-DEHYDRO-3-DEOXY-GALACTARATE ALDOLASE FROM ESCHERICHIA COLI'''
'''2-DEHYDRO-3-DEOXY-GALACTARATE ALDOLASE FROM ESCHERICHIA COLI'''
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[[Category: Blackwell, N C.]]
[[Category: Blackwell, N C.]]
[[Category: Izard, T.]]
[[Category: Izard, T.]]
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[[Category: class ii aldolase]]
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[[Category: Class ii aldolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:23:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:50:40 2008''
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Revision as of 11:23, 2 May 2008

Image:1dxe.gif

Template:STRUCTURE 1dxe

2-DEHYDRO-3-DEOXY-GALACTARATE ALDOLASE FROM ESCHERICHIA COLI


Overview

Carbon-carbon bond formation is an essential reaction in organic chemistry and the use of aldolase enzymes for the stereochemical control of such reactions is an attractive alternative to conventional chemical methods. Here we describe the crystal structures of a novel class II enzyme, 2-dehydro-3-deoxy-galactarate (DDG) aldolase from Escherichia coli, in the presence and absence of substrate. The crystal structure was determined by locating only four Se sites to obtain phases for 506 protein residues. The protomer displays a modified (alpha/beta)(8) barrel fold, in which the eighth alpha-helix points away from the beta-barrel instead of packing against it. Analysis of the DDG aldolase crystal structures suggests a novel aldolase mechanism in which a phosphate anion accepts the proton from the methyl group of pyruvate.

About this Structure

1DXE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structures of the metal-dependent 2-dehydro-3-deoxy-galactarate aldolase suggest a novel reaction mechanism., Izard T, Blackwell NC, EMBO J. 2000 Aug 1;19(15):3849-56. PMID:10921867 Page seeded by OCA on Fri May 2 14:23:40 2008

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