1dxj

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[[Image:1dxj.gif|left|200px]]
[[Image:1dxj.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1dxj |SIZE=350|CAPTION= <scene name='initialview01'>1dxj</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1dxj", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1dxj| PDB=1dxj | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxj OCA], [http://www.ebi.ac.uk/pdbsum/1dxj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dxj RCSB]</span>
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}}
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'''STRUCTURE OF THE CHITINASE FROM JACK BEAN'''
'''STRUCTURE OF THE CHITINASE FROM JACK BEAN'''
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[[Category: Hohne, W.]]
[[Category: Hohne, W.]]
[[Category: Schlesier, B.]]
[[Category: Schlesier, B.]]
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[[Category: alpha helical protein]]
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[[Category: Alpha helical protein]]
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[[Category: family 19 glycosidase]]
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[[Category: Family 19 glycosidase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:23:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:50:45 2008''
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Revision as of 11:23, 2 May 2008

Image:1dxj.gif

Template:STRUCTURE 1dxj

STRUCTURE OF THE CHITINASE FROM JACK BEAN


Overview

The structure of jack bean chitinase was solved at 1.8 A resolution by molecular replacement. It is an alpha-helical protein with three disulfide bridges. The active site is related in structure to animal and viral lysozymes. However, unlike in lysozyme, the architecture of the active site suggests a single-step cleavage. According to this mechanism, Glu68 is the proton donor and Glu90 assists in the reaction by moving towards the substrate and recruiting a water molecule that acts as the nucleophile. In this model, a water molecule was found in contact with Glu90 O(epsilon1) and Thr119 O(gamma) at a distance of 3.0 and 2.8 A, respectively. The model is in accordance with the observed inversion mechanism.

About this Structure

1DXJ is a Single protein structure of sequence from Canavalia ensiformis. Full crystallographic information is available from OCA.

Reference

Structure of jack bean chitinase., Hahn M, Hennig M, Schlesier B, Hohne W, Acta Crystallogr D Biol Crystallogr. 2000 Sep;56(Pt 9):1096-9. PMID:10957628 Page seeded by OCA on Fri May 2 14:23:55 2008

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