7c6o
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Catalytic Subunit of Cobaltochelatase from Mycobacterium tuberculosis== | ==Catalytic Subunit of Cobaltochelatase from Mycobacterium tuberculosis== | ||
| - | <StructureSection load='7c6o' size='340' side='right'caption='[[7c6o]]' scene=''> | + | <StructureSection load='7c6o' size='340' side='right'caption='[[7c6o]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C6O OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[7c6o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C6O FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cobN, DSI38_03330, ERS023446_03562, ERS094182_01916, F6W99_00653, GJE03_10820 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ligase Ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.6.1.2 6.6.1.2] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c6o OCA], [https://pdbe.org/7c6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c6o RCSB], [https://www.ebi.ac.uk/pdbsum/7c6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c6o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cobaltochelatase in aerobic cobalamin biosynthesis is a complex composed of three subunits. The large subunit CobN is a 140-kDa protein and is homologous to the ChlH subunit of magnesium chelatase. Previously we have reported the 2.5-A structure of a cyanobacterial ChlH. Here we present the 1.8-A structure of CobN from Mycobacterium tuberculosis. The overall structure of CobN and ChlH is similar, but significant difference occurs in the head domain. Structural comparison of domains between the two proteins unravels candidate regions for substrate binding and helps to locate a triad of residues that may be essential for metal ion binding. | ||
| + | |||
| + | Crystal structure of the large subunit of cobaltochelatase from Mycobacterium tuberculosis.,Zhang JH, Yuan H, Wang X, Dai HE, Zhang M, Liu L Proteins. 2021 Apr;89(4):462-467. doi: 10.1002/prot.26023. Epub 2020 Nov 28. PMID:33210347<ref>PMID:33210347</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7c6o" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Liu L]] | + | [[Category: Ligase]] |
| - | [[Category: Zhang J]] | + | [[Category: Liu, L]] |
| + | [[Category: Zhang, J]] | ||
| + | [[Category: Co-chelatase]] | ||
| + | [[Category: Metal binding protein]] | ||
Revision as of 06:59, 17 March 2021
Catalytic Subunit of Cobaltochelatase from Mycobacterium tuberculosis
| |||||||||||
