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2h7t
From Proteopedia
(Difference between revisions)
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==Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein 2 (IGFBP-2)== | ==Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein 2 (IGFBP-2)== | ||
| - | <StructureSection load='2h7t' size='340' side='right' caption='[[2h7t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2h7t' size='340' side='right'caption='[[2h7t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2h7t]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2h7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H7T FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGFBP2, BP2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGFBP2, BP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h7t OCA], [https://pdbe.org/2h7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h7t RCSB], [https://www.ebi.ac.uk/pdbsum/2h7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h7t ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/IBP2_HUMAN IBP2_HUMAN]] Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.<ref>PMID:19081843</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Insulin-like growth factor binding protein|Insulin-like growth factor binding protein]] | + | *[[Insulin-like growth factor binding protein 3D structures|Insulin-like growth factor binding protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Kuang, Z]] | [[Category: Kuang, Z]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Thyroglobulin type 1 fold]] | [[Category: Thyroglobulin type 1 fold]] | ||
Current revision
Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein 2 (IGFBP-2)
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