5o9b
From Proteopedia
(Difference between revisions)
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<StructureSection load='5o9b' size='340' side='right'caption='[[5o9b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='5o9b' size='340' side='right'caption='[[5o9b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5o9b]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5o9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O9B FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GATA2 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GATA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9b OCA], [https://pdbe.org/5o9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o9b RCSB], [https://www.ebi.ac.uk/pdbsum/5o9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9b ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/GATA2_HUMAN GATA2_HUMAN]] Deafness-lymphedema-leukemia syndrome;Inherited acute myeloid leukemia;Myelodysplastic syndrome;Monocytopenia with susceptibility to infections. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/GATA2_HUMAN GATA2_HUMAN]] Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:10, 18 March 2021
Solution NMR structure of human GATA2 C-terminal zinc finger domain
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