1dyt

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[[Image:1dyt.gif|left|200px]]
[[Image:1dyt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1dyt |SIZE=350|CAPTION= <scene name='initialview01'>1dyt</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1dyt", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ASA:Potential+Active+Site+Chain+A'>ASA</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= RNASE3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1dyt| PDB=1dyt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dyt OCA], [http://www.ebi.ac.uk/pdbsum/1dyt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dyt RCSB]</span>
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}}
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'''X-RAY CRYSTAL STRUCTURE OF ECP (RNASE 3) AT 1.75 A'''
'''X-RAY CRYSTAL STRUCTURE OF ECP (RNASE 3) AT 1.75 A'''
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[[Category: Tada, H.]]
[[Category: Tada, H.]]
[[Category: Yamada, H.]]
[[Category: Yamada, H.]]
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[[Category: ecp]]
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[[Category: Ecp]]
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[[Category: eosinophil cationic protein]]
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[[Category: Eosinophil cationic protein]]
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[[Category: rnase 3]]
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[[Category: Rnase 3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:26:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:51:34 2008''
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Revision as of 11:26, 2 May 2008

Image:1dyt.gif

Template:STRUCTURE 1dyt

X-RAY CRYSTAL STRUCTURE OF ECP (RNASE 3) AT 1.75 A


Overview

Eosinophil cationic protein (ECP; RNase 3) is a human ribonuclease found only in eosinophil leukocytes that belongs to the RNase A superfamily. This enzyme is bactericidal, helminthotoxic and cytotoxic to mammalian cells and tissues. The protein has been cloned, heterologously overexpressed, purified and crystallized. Its crystal structure has been determined and refined using data up to 1. 75 A resolution. The molecule displays the alpha+beta folding topology typical for members of the ribonuclease A superfamily. The catalytic active site residues are conserved with respect to other ribonucleases of the superfamily but some differences appear at substrate recognition subsites, which may account, in part, for the low catalytic activity. Most strikingly, 19 surface-located arginine residues confer a strong basic character to the protein. The high concentration of positive charges and the particular orientation of the side-chains of these residues may also be related to the low activity of ECP as a ribonuclease and provides an explanation for its unique cytotoxic role through cell membrane disruption.

About this Structure

1DYT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution., Mallorqui-Fernandez G, Pous J, Peracaula R, Aymami J, Maeda T, Tada H, Yamada H, Seno M, de Llorens R, Gomis-Ruth FX, Coll M, J Mol Biol. 2000 Jul 28;300(5):1297-307. PMID:10903870 Page seeded by OCA on Fri May 2 14:26:51 2008

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