1dzf

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[[Image:1dzf.jpg|left|200px]]
[[Image:1dzf.jpg|left|200px]]
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{{Structure
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|PDB= 1dzf |SIZE=350|CAPTION= <scene name='initialview01'>1dzf</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1dzf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= YBR154C OR YBR1204 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_1dzf| PDB=1dzf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzf OCA], [http://www.ebi.ac.uk/pdbsum/1dzf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dzf RCSB]</span>
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'''RPB5 FROM S.CEREVISIAE'''
'''RPB5 FROM S.CEREVISIAE'''
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[[Category: Todone, F.]]
[[Category: Todone, F.]]
[[Category: Weinzierl, R O.J.]]
[[Category: Weinzierl, R O.J.]]
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[[Category: rna polymerase subunit]]
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[[Category: Rna polymerase subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:28:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:51:58 2008''
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Revision as of 11:28, 2 May 2008

Image:1dzf.jpg

Template:STRUCTURE 1dzf

RPB5 FROM S.CEREVISIAE


Overview

Eukaryotic nuclei contain three different types of RNA polymerases (RNAPs), each consisting of 12-18 different subunits. The evolutionarily highly conserved RNAP subunit RPB5 is shared by all three enzymes and therefore represents a key structural/functional component of all eukaryotic RNAPs. Here we present the crystal structure of the RPB5 subunit from Saccharomyces cerevisiae. The bipartite structure includes a eukaryote-specific N-terminal domain and a C-terminal domain resembling the archaeal RNAP subunit H. RPB5 has been implicated in direct protein-protein contacts with transcription factor IIB, one of the components of the RNAP(II) basal transcriptional machinery, and gene-specific activator proteins, such as the hepatitis B virus transactivator protein X. The experimentally mapped regions of RPB5 involved in these interactions correspond to distinct and surface-exposed alpha-helical structures.

About this Structure

1DZF is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of RPB5, a universal eukaryotic RNA polymerase subunit and transcription factor interaction target., Todone F, Weinzierl RO, Brick P, Onesti S, Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6306-10. PMID:10841537 Page seeded by OCA on Fri May 2 14:28:16 2008

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