1fyg
From Proteopedia
(Difference between revisions)
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<StructureSection load='1fyg' size='340' side='right'caption='[[1fyg]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''> | <StructureSection load='1fyg' size='340' side='right'caption='[[1fyg]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1fyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYG OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[1fyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYG FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyg OCA], [https://pdbe.org/1fyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyg RCSB], [https://www.ebi.ac.uk/pdbsum/1fyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyg ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CO13_CONST CO13_CONST]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This peptide selectively targets N-type voltage-gated calcium channels (Cav2.2/CACNA1B). Displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of MVIIA injected intrathecally.<ref>PMID:15880145</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 07:09, 24 March 2021
Solution structure of omega conotoxin SO3 determined by 1H-NMR
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Categories: Large Structures | Yan, Y | Zhang, R | Beta sheet | Toxin
