1a17
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(New page: 200px<br /> <applet load="1a17" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a17, resolution 2.45Å" /> '''TETRATRICOPEPTIDE R...)
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Revision as of 13:47, 12 November 2007
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TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5
Overview
The tetratricopeptide repeat (TPR) is a degenerate 34 amino acid sequence, identified in a wide variety of proteins, present in tandem arrays of 3-16, motifs, which form scaffolds to mediate protein-protein interactions and, often the assembly of multiprotein complexes. TPR-containing proteins, include the anaphase promoting complex (APC) subunits cdc16, cdc23 and, cdc27, the NADPH oxidase subunit p67 phox, hsp90-binding immunophilins, transcription factors, the PKR protein kinase inhibitor, and peroxisomal, and mitochondrial import proteins. Here, we report the crystal structure, of the TPR domain of a protein phosphatase, PP5. Each of the three TPR, motifs of this domain consist of a pair of antiparallel alpha-helices of, equivalent length. Adjacent TPR motifs are packed together in a parallel, arrangement such that a tandem TPR motif structure is composed of a, regular series of antiparallel alpha-helices. The uniform angular and, spatial arrangement of neighbouring alpha-helices defines a helical, structure and creates an amphipathic groove. Multiple-TPR motif proteins, would fold into a right-handed super-helical structure with a continuous, helical groove suitable for the recognition of target proteins, hence, defining a novel mechanism for protein recognition. The spatial, arrangement of alpha-helices in the PP5-TPR domain is similar to those, within 14-3-3 proteins.
About this Structure
1A17 is a Single protein structure of sequence from Homo sapiens with SO4 as ligand. Active as Phosphoprotein phosphatase, with EC number 3.1.3.16 Full crystallographic information is available from OCA.
Reference
The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions., Das AK, Cohen PW, Barford D, EMBO J. 1998 Mar 2;17(5):1192-9. PMID:9482716
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