1e07
From Proteopedia
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'''THEORETICAL MODEL OF HUMAN CARCINOEMBRYONIC ANTIGEN BY HOMOLOGY MODELLING AND CURVE-FITTING TO EXPERIMENTAL SOLUTION SCATTERING DATA''' | '''THEORETICAL MODEL OF HUMAN CARCINOEMBRYONIC ANTIGEN BY HOMOLOGY MODELLING AND CURVE-FITTING TO EXPERIMENTAL SOLUTION SCATTERING DATA''' | ||
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[[Category: Boehm, M K.]] | [[Category: Boehm, M K.]] | ||
[[Category: Perkins, S J.]] | [[Category: Perkins, S J.]] | ||
| - | [[Category: | + | [[Category: Calpha only]] |
| - | [[Category: | + | [[Category: Cea]] |
| - | [[Category: | + | [[Category: Immunoglobulin-fold]] |
| - | [[Category: | + | [[Category: Tumour marker]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:29:45 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 11:29, 2 May 2008
THEORETICAL MODEL OF HUMAN CARCINOEMBRYONIC ANTIGEN BY HOMOLOGY MODELLING AND CURVE-FITTING TO EXPERIMENTAL SOLUTION SCATTERING DATA
Overview
MFE23 is a single chain Fv antibody that has a high affinity for carcinoembryonic antigen (CEA). A full homology model for CEA based on V-type, I-type and C2-type immunoglobulin folds, 28 oligosaccharides and the interdomain angle of CD2 was validated using solution scattering data. The superimposition of the intermolecular contacts observed in our recent crystal structure of MFE23 with the N-terminal domain of CEA permitted the MFE23-CEA complex to be modelled. Good surface and electrostatic complementarity and carbohydrate-unhindered access of MFE23 with the indentation between the first two CEA domains was observed. The model is supported by biochemical data and provides insight on the high affinity of MFE23 for CEA.
About this Structure
1E07 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23., Boehm MK, Perkins SJ, FEBS Lett. 2000 Jun 9;475(1):11-6. PMID:10854848 Page seeded by OCA on Fri May 2 14:29:45 2008
