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User:Tori Templin/Sandbox 1
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Acyl-Coenzyme A Cholesterol Acyltransferase (ACAT), or also known as Sterol ''O''-Acyltransferase (SOAT), is an important enzyme in the body. | Acyl-Coenzyme A Cholesterol Acyltransferase (ACAT), or also known as Sterol ''O''-Acyltransferase (SOAT), is an important enzyme in the body. | ||
Cholesterol esters were discovered in arterial lesions in 1910. Between 1980-1995, the interest in ACAT inhibitors grew, but some of the compounds looked at exhibited toxicity. In 1993, an ACAT gene was successfully cloned. This discovery led to more studies with ACAT and atherosclerosis. | Cholesterol esters were discovered in arterial lesions in 1910. Between 1980-1995, the interest in ACAT inhibitors grew, but some of the compounds looked at exhibited toxicity. In 1993, an ACAT gene was successfully cloned. This discovery led to more studies with ACAT and atherosclerosis. | ||
| - | add more history | + | <ref name=”Farese Jr.”>PMID: 16857957</ref> |
| + | add more history | ||
[[Image:Screen Shot 2021-03-16 at 3.11.39 PM.png|400 px|right|thumb|Figure 1. ACAT as a Dimer of Dimers]] | [[Image:Screen Shot 2021-03-16 at 3.11.39 PM.png|400 px|right|thumb|Figure 1. ACAT as a Dimer of Dimers]] | ||
Revision as of 18:23, 30 March 2021
Acyl-Coenzyme A Cholesterol Acyltransferase
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References
- ↑ Farese RV Jr. The nine lives of ACAT inhibitors. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1684-6. doi:, 10.1161/01.ATV.0000227511.35456.90. PMID:16857957 doi:http://dx.doi.org/10.1161/01.ATV.0000227511.35456.90
- ↑ Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L. Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun. 2020 May 18;11(1):2478. doi: 10.1038/s41467-020-16288-4. PMID:32424158 doi:http://dx.doi.org/10.1038/s41467-020-16288-4
- ↑ Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 May;581(7808):333-338. doi: 10.1038/s41586-020-2290-0. Epub 2020 May, 13. PMID:32433614 doi:http://dx.doi.org/10.1038/s41586-020-2290-0
Student Contributors
- Tori Templin
- Haylie Moehlenkamp
- Megan Fleshman
