User:Megan Fleshman/Sandbox1

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The <scene name='87/877605/T_tunnel_residues/1'>residues</scene> that constitute the T tunnel are critical to the activity of ACAT1.
The <scene name='87/877605/T_tunnel_residues/1'>residues</scene> that constitute the T tunnel are critical to the activity of ACAT1.
<scene name='87/877605/T_tunnel/1'>T tunnel</scene>
<scene name='87/877605/T_tunnel/1'>T tunnel</scene>
 +
<scene name='87/877605/L_tunnel/1'>L tunnel</scene>

Revision as of 19:50, 30 March 2021

ACAT

Drag the structure with the mouse to rotate

References

  1. Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
  2. Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 May;581(7808):333-338. doi: 10.1038/s41586-020-2290-0. Epub 2020 May, 13. PMID:32433614 doi:http://dx.doi.org/10.1038/s41586-020-2290-0
  3. Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L. Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun. 2020 May 18;11(1):2478. doi: 10.1038/s41467-020-16288-4. PMID:32424158 doi:http://dx.doi.org/10.1038/s41467-020-16288-4

Student Contributors

  • Megan Fleshman

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Megan Fleshman

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