User:Tori Templin/Sandbox 1

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<ref name=”Farese Jr.”>PMID: 16857957</ref>
<ref name=”Farese Jr.”>PMID: 16857957</ref>
add more history
add more history
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[[Image:Screen Shot 2021-03-16 at 3.11.39 PM.png|400 px|right|thumb|Figure 1. ACAT as a Dimer of Dimers]]
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[[Image:Screen Shot 2021-03-16 at 3.11.39 PM.png|400 px|right|thumb|Figure 1. ACAT as a Dimer of Dimers - One Monomer is Highlighted]]
== Function ==
== Function ==

Revision as of 19:52, 30 March 2021

Acyl-Coenzyme A Cholesterol Acyltransferase

ACAT Tetramer

Drag the structure with the mouse to rotate

References

  1. Farese RV Jr. The nine lives of ACAT inhibitors. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1684-6. doi:, 10.1161/01.ATV.0000227511.35456.90. PMID:16857957 doi:http://dx.doi.org/10.1161/01.ATV.0000227511.35456.90
  2. Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L. Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun. 2020 May 18;11(1):2478. doi: 10.1038/s41467-020-16288-4. PMID:32424158 doi:http://dx.doi.org/10.1038/s41467-020-16288-4
  3. Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 May;581(7808):333-338. doi: 10.1038/s41586-020-2290-0. Epub 2020 May, 13. PMID:32433614 doi:http://dx.doi.org/10.1038/s41586-020-2290-0

Student Contributors

  • Tori Templin
  • Haylie Moehlenkamp
  • Megan Fleshman

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Tori Templin

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