1e0l

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e0l OCA], [http://www.ebi.ac.uk/pdbsum/1e0l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e0l RCSB]</span>
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'''FBP28WW DOMAIN FROM MUS MUSCULUS'''
'''FBP28WW DOMAIN FROM MUS MUSCULUS'''
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[[Category: Macias, M J.]]
[[Category: Macias, M J.]]
[[Category: Oschkinat, H.]]
[[Category: Oschkinat, H.]]
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[[Category: fbp28]]
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[[Category: Fbp28]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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[[Category: ww domain]]
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[[Category: Ww domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:30:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:52:31 2008''
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Revision as of 11:30, 2 May 2008

Template:STRUCTURE 1e0l

FBP28WW DOMAIN FROM MUS MUSCULUS


Overview

Two new NMR structures of WW domains, the mouse formin binding protein and a putative 84.5 kDa protein from Saccharomyces cerevisiae, show that this domain, only 35 amino acids in length, defines the smallest monomeric triple-stranded antiparallel beta-sheet protein domain that is stable in the absence of disulfide bonds, tightly bound ions or ligands. The structural roles of conserved residues have been studied using site-directed mutagenesis of both wild type domains. Crucial interactions responsible for the stability of the WW structure have been identified. Based on a network of highly conserved long range interactions across the beta-sheet structure that supports the WW fold and on a systematic analysis of conserved residues in the WW family, we have designed a folded prototype WW sequence.

About this Structure

1E0L is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural analysis of WW domains and design of a WW prototype., Macias MJ, Gervais V, Civera C, Oschkinat H, Nat Struct Biol. 2000 May;7(5):375-9. PMID:10802733 Page seeded by OCA on Fri May 2 14:30:42 2008

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