1a1n
From Proteopedia
(New page: 200px<br /> <applet load="1a1n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a1n, resolution 2.0Å" /> '''MHC CLASS I MOLECULE...) |
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==Overview== | ==Overview== | ||
The crystal structure of the human major histocompatibility complex class, I B allele HLA B*3501 complexed with the 8-mer peptide epitope HIV1 Nef, 75-82 (VPLRPMTY) has been determined at 2.0 angstrom resolution., Comparison with the crystal structure of the closely related allele HLA, B*5301 reveals the structural basis for the tyrosine specificity of the, B*3501 F pocket. The structure also reveals a novel conformation of the, 8-mer peptide within the binding groove. The positions of the peptide N, and C termini are nonstandard, but the classic pattern of hydrogen bonding, to nonpolymorphic MHC class I residues is maintained, at the N terminus by, addition of a water molecule, and at the C terminus by a substantial shift, in the alpha 2 helix. | The crystal structure of the human major histocompatibility complex class, I B allele HLA B*3501 complexed with the 8-mer peptide epitope HIV1 Nef, 75-82 (VPLRPMTY) has been determined at 2.0 angstrom resolution., Comparison with the crystal structure of the closely related allele HLA, B*5301 reveals the structural basis for the tyrosine specificity of the, B*3501 F pocket. The structure also reveals a novel conformation of the, 8-mer peptide within the binding groove. The positions of the peptide N, and C termini are nonstandard, but the classic pattern of hydrogen bonding, to nonpolymorphic MHC class I residues is maintained, at the N terminus by, addition of a water molecule, and at the C terminus by a substantial shift, in the alpha 2 helix. | ||
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| + | ==Disease== | ||
| + | Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142830 142830]], Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]], Spondyloarthropathy, susceptibility to, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142830 142830]], Stevens-Johnson syndrome, carbamazepine-induced, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142830 142830]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: nef]] | [[Category: nef]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 15:54:20 2007'' |
Revision as of 13:47, 12 November 2007
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MHC CLASS I MOLECULE B*3501 COMPLEXED WITH PEPTIDE VPLRPMTY FROM THE NEF PROTEIN (75-82) OF HIV1
Contents |
Overview
The crystal structure of the human major histocompatibility complex class, I B allele HLA B*3501 complexed with the 8-mer peptide epitope HIV1 Nef, 75-82 (VPLRPMTY) has been determined at 2.0 angstrom resolution., Comparison with the crystal structure of the closely related allele HLA, B*5301 reveals the structural basis for the tyrosine specificity of the, B*3501 F pocket. The structure also reveals a novel conformation of the, 8-mer peptide within the binding groove. The positions of the peptide N, and C termini are nonstandard, but the classic pattern of hydrogen bonding, to nonpolymorphic MHC class I residues is maintained, at the N terminus by, addition of a water molecule, and at the C terminus by a substantial shift, in the alpha 2 helix.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142830], Hypoproteinemia, hypercatabolic OMIM:[109700], Spondyloarthropathy, susceptibility to, 1 OMIM:[142830], Stevens-Johnson syndrome, carbamazepine-induced, susceptibility to OMIM:[142830]
About this Structure
1A1N is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501., Smith KJ, Reid SW, Stuart DI, McMichael AJ, Jones EY, Bell JI, Immunity. 1996 Mar;4(3):203-13. PMID:8624811
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