1e0s

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1e0s.jpg|left|200px]]
[[Image:1e0s.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1e0s |SIZE=350|CAPTION= <scene name='initialview01'>1e0s</scene>, resolution 2.28&Aring;
+
The line below this paragraph, containing "STRUCTURE_1e0s", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1e0s| PDB=1e0s | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e0s OCA], [http://www.ebi.ac.uk/pdbsum/1e0s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e0s RCSB]</span>
+
-
}}
+
'''SMALL G PROTEIN ARF6-GDP'''
'''SMALL G PROTEIN ARF6-GDP'''
Line 27: Line 24:
[[Category: Cherfils, J.]]
[[Category: Cherfils, J.]]
[[Category: Menetrey, J.]]
[[Category: Menetrey, J.]]
-
[[Category: arf]]
+
[[Category: Arf]]
-
[[Category: arf6]]
+
[[Category: Arf6]]
-
[[Category: g protein]]
+
[[Category: G protein]]
-
[[Category: membrane traffic]]
+
[[Category: Membrane traffic]]
-
[[Category: ra]]
+
[[Category: Ra]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:31:01 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:52:42 2008''
+

Revision as of 11:31, 2 May 2008

Image:1e0s.jpg

Template:STRUCTURE 1e0s

SMALL G PROTEIN ARF6-GDP


Overview

Arf6 is an isoform of Arf that localizes at the periphery of the cell where it has an essential role in endocytotic pathways. Its function does not overlap with that of Arf1, although the two proteins share approximately 70% sequence identity and they have switch regions, whose conformation depends on the nature of the guanine nucleotide, with almost identical sequences. The crystal structure of Arf6-GDP at 2.3 A shows that it has a conformation similar to that of Arf1-GDP, which cannot bind membranes with high affinity. Significantly, the switch regions of Arf6 deviate by 2-5 A from those of Arf1. These differences are a consequence of the shorter N-terminal linker of Arf6 and of discrete sequence changes between Arf6 and Arf1. Mutational analysis shows that one of the positions which differs between Arf1 and Arf6 affects the configuration of the nucleotide binding site and thus the nucleotide binding properties of the Arf variant. Altogether, our results provide a structural basis for understanding how Arf1 and Arf6 can be distinguished by their guanine nucleotide exchange factors and suggest a model for the nucleotide/membrane cycle of Arf6.

About this Structure

1E0S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity., Menetrey J, Macia E, Pasqualato S, Franco M, Cherfils J, Nat Struct Biol. 2000 Jun;7(6):466-9. PMID:10881192 Page seeded by OCA on Fri May 2 14:31:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1e0s"
Personal tools