7daz
From Proteopedia
(Difference between revisions)
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==Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in TDP015- and GSH-bound form== | ==Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in TDP015- and GSH-bound form== | ||
| - | <StructureSection load='7daz' size='340' side='right'caption='[[7daz]]' scene=''> | + | <StructureSection load='7daz' size='340' side='right'caption='[[7daz]], [[Resolution|resolution]] 1.64Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DAZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7daz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DAZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7daz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7daz OCA], [https://pdbe.org/7daz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7daz RCSB], [https://www.ebi.ac.uk/pdbsum/7daz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7daz ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=H29:6-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)pyridin-3-amine'>H29</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6kem|6kem]]</div></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GstE14, GSTD14-14, nobo, CG4688 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7daz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7daz OCA], [https://pdbe.org/7daz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7daz RCSB], [https://www.ebi.ac.uk/pdbsum/7daz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7daz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/GSTEE_DROME GSTEE_DROME]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25344753, PubMed:25300303). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref> <ref>PMID:25300303</ref> <ref>PMID:25344753</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Drome]] | ||
| + | [[Category: Glutathione transferase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Inaba K]] | + | [[Category: Inaba, K]] |
| - | [[Category: Koiwai K]] | + | [[Category: Koiwai, K]] |
| - | [[Category: Niwa R]] | + | [[Category: Niwa, R]] |
| - | [[Category: Senda T]] | + | [[Category: Senda, T]] |
| - | [[Category: Yumoto F]] | + | [[Category: Yumoto, F]] |
| + | [[Category: Drosophila melanogaster]] | ||
| + | [[Category: Ecdysteroid]] | ||
| + | [[Category: Glutathione s-transferase]] | ||
| + | [[Category: Gst]] | ||
| + | [[Category: Gste14]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 10:48, 31 March 2021
Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in TDP015- and GSH-bound form
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