1a3k
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(New page: 200px<br /> <applet load="1a3k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a3k, resolution 2.1Å" /> '''X-RAY CRYSTAL STRUCT...)
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Revision as of 13:48, 12 November 2007
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X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION
Overview
Galectins are a family of lectins which share similar carbohydrate, recognition domains (CRDs) and affinity for small beta-galactosides, but, which show significant differences in binding specificity for more complex, glycoconjugates. We report here the x-ray crystal structure of the human, galectin-3 CRD, in complex with lactose and N-acetyllactosamine, at 2.1-A, resolution. This structure represents the first example of a CRD, determined from a galectin which does not show the canonical 2-fold, symmetric dimer organization. Comparison with the published structures of, galectins-1 and -2 provides an explanation for the differences in, carbohydrate-binding specificity shown by galectin-3, and for the fact, that it fails to form dimers by analogous CRD-CRD interactions.
About this Structure
1A3K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution., Seetharaman J, Kanigsberg A, Slaaby R, Leffler H, Barondes SH, Rini JM, J Biol Chem. 1998 May 22;273(21):13047-52. PMID:9582341
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