User:Dustin Soe/Sandbox 1
From Proteopedia
(Difference between revisions)
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| - | + | =Lipoprotein Lipase Structure= | |
<StructureSection load='6OB0' size='350' frame='true' side='right' caption='Lipoprotein Lipase Biological Assembly' scene=''> | <StructureSection load='6OB0' size='350' frame='true' side='right' caption='Lipoprotein Lipase Biological Assembly' scene=''> | ||
==Introduction== | ==Introduction== | ||
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The function of this lipase is to hydrolyze triglycerides of very low density lipoproteins (VLDL) and to aid in the delivery of lipid nutrients to vital tissues. | The function of this lipase is to hydrolyze triglycerides of very low density lipoproteins (VLDL) and to aid in the delivery of lipid nutrients to vital tissues. | ||
==Mechanism== | ==Mechanism== | ||
| - | The transition state of the catalytic triad is stabilized by the <scene name='87/877516/Oxyanion_hole_master/1'>Oxyanion Hole</scene>. <scene name='87/877516/Catalytic_triad_master/1'>Catalytic Triad</scene> | + | [[Image:LPL_mech.png|400 px|left|thumb|Serine hydrolase mechanism utilized by LPL to catalyze the breakdown of one ester bond of a triglyceride]] |
| + | The transition state of the catalytic triad is stabilized by the <scene name='87/877516/Oxyanion_hole_master/1'>Oxyanion Hole</scene>. <scene name='87/877516/Catalytic_triad_master/1'>Catalytic Triad</scene> | ||
== Relevance & Disease == | == Relevance & Disease == | ||
LPL is an extremely important enzyme, in that it breaks down triglycerides carried on VLDL, which leads to the reduction of cholesterol buildup. Cholesterol build up is a very serious issue with regards to obesity in the United States. In addition to this, increased plasma triglyceride levels (hypertriglyceridemia) is very unhealthy and is the leading cause of Coronary Artery Disease in America. LPL is an enzyme that helps combat this disease by breaking down the excess triglycerides that block the arteries of your heart. Very similarly, Chylomicronemia, a high level of triglycerides in the blood, causes buildup of chylomicrons (ultra-low-density lipoproteins) and leads to similar diseases. Without LPL in the body, developing coronary & metabolic (liver & pancreas) based diseases are at a higher likelihood | LPL is an extremely important enzyme, in that it breaks down triglycerides carried on VLDL, which leads to the reduction of cholesterol buildup. Cholesterol build up is a very serious issue with regards to obesity in the United States. In addition to this, increased plasma triglyceride levels (hypertriglyceridemia) is very unhealthy and is the leading cause of Coronary Artery Disease in America. LPL is an enzyme that helps combat this disease by breaking down the excess triglycerides that block the arteries of your heart. Very similarly, Chylomicronemia, a high level of triglycerides in the blood, causes buildup of chylomicrons (ultra-low-density lipoproteins) and leads to similar diseases. Without LPL in the body, developing coronary & metabolic (liver & pancreas) based diseases are at a higher likelihood | ||
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== Structural highlights == | == Structural highlights == | ||
| - | This will be the structural highlights | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 19:14, 5 April 2021
Lipoprotein Lipase Structure
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References
Student Contributors
- Giselle Flores
- Dustin Soe
- Maggie Stopa
