User:Dustin Soe/Sandbox 1
From Proteopedia
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LPL is an extremely important enzyme, in that it breaks down triglycerides carried on VLDL, which leads to the reduction of cholesterol buildup. Cholesterol build up is a very serious issue with regards to obesity in the United States. In addition to this, increased plasma triglyceride levels (hypertriglyceridemia) is very unhealthy and is the leading cause of Coronary Artery Disease in America. LPL is an enzyme that helps combat this disease by breaking down the excess triglycerides that block the arteries of your heart. Very similarly, Chylomicronemia, a high level of triglycerides in the blood, causes buildup of chylomicrons (ultra-low-density lipoproteins) and leads to similar diseases. Without LPL in the body, developing coronary & metabolic (liver & pancreas) based diseases are at a higher likelihood | LPL is an extremely important enzyme, in that it breaks down triglycerides carried on VLDL, which leads to the reduction of cholesterol buildup. Cholesterol build up is a very serious issue with regards to obesity in the United States. In addition to this, increased plasma triglyceride levels (hypertriglyceridemia) is very unhealthy and is the leading cause of Coronary Artery Disease in America. LPL is an enzyme that helps combat this disease by breaking down the excess triglycerides that block the arteries of your heart. Very similarly, Chylomicronemia, a high level of triglycerides in the blood, causes buildup of chylomicrons (ultra-low-density lipoproteins) and leads to similar diseases. Without LPL in the body, developing coronary & metabolic (liver & pancreas) based diseases are at a higher likelihood | ||
== Structural highlights == | == Structural highlights == | ||
| - | + | Image of N terminal with active site | |
| - | + | Image of C terminal domain | |
| - | + | <scene name='87/877513/Active_site/1'>active site</scene> | |
| - | + | ||
<scene name='87/877516/Dustin_1/1'>Text To Be Displayed</scene> | <scene name='87/877516/Dustin_1/1'>Text To Be Displayed</scene> | ||
| - | </StructureSection> | ||
| - | [[Image:LPL.jpg|700 px|left|thumb|Figure 1. The coolest image of this protein EVAH!!!]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| - | + | Arora R, Nimonkar AV, Baird D, Wang C, Chiu CH, Horton PA, Hanrahan S, Cubbon R, Weldon S, Tschantz WR, Mueller S, Brunner R, Lehr P, Meier P, Ottl J, Voznesensky A, Pandey P, Smith TM, Stojanovic A, Flyer A, Benson TE, Romanowski MJ, Trauger JW. Structure of lipoprotein lipase in complex with GPIHBP1. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10360-10365. doi:, 10.1073/pnas.1820171116. Epub 2019 May 9. PMID:31072929doi:http://dx.doi.org/10.1073/pnas.1820171116 | |
==Student Contributors== | ==Student Contributors== | ||
*Giselle Flores | *Giselle Flores | ||
*Dustin Soe | *Dustin Soe | ||
*Maggie Stopa | *Maggie Stopa | ||
Revision as of 19:22, 5 April 2021
Lipoprotein Lipase Structure
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