1e42

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[[Image:1e42.gif|left|200px]]
[[Image:1e42.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1e42 |SIZE=350|CAPTION= <scene name='initialview01'>1e42</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1e42", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mo5+Binding+Site+For+Chain+A+Symmetry+Related+Subunits+C+...'>AC1</scene>, <scene name='pdbsite=AC2:Mo5+Binding+Site+For+Chain+B+Symmetry+Related+Subunits+C+...'>AC2</scene>, <scene name='pdbsite=AC3:Mo5+Binding+Site+For+Chain+B+Symmetry+Related+Subunits+C+...'>AC3</scene>, <scene name='pdbsite=AC4:Mo5+Binding+Site+For+Chain+B+Symmetry+Related+Subunits+C+...'>AC4</scene> and <scene name='pdbsite=AC5:Nik+Binding+Site+For+Chain+B+Symmetry+Related+Subunits+C+...'>AC5</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1e42| PDB=1e42 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e42 OCA], [http://www.ebi.ac.uk/pdbsum/1e42 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e42 RCSB]</span>
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}}
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'''BETA2-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2'''
'''BETA2-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2'''
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[[Category: Mcmahon, H T.]]
[[Category: Mcmahon, H T.]]
[[Category: Owen, D J.]]
[[Category: Owen, D J.]]
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[[Category: adaptor]]
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[[Category: Adaptor]]
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[[Category: endocytosis]]
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[[Category: Endocytosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:38:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:54:40 2008''
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Revision as of 11:38, 2 May 2008

Image:1e42.gif

Template:STRUCTURE 1e42

BETA2-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2


Overview

The heterotetrameric AP2 adaptor (alpha, beta 2, mu 2 and sigma 2 subunits) plays a central role in clathrin-mediated endocytosis. We present the protein recruitment function and 1.7 A resolution structure of its beta 2-appendage domain to complement those previously determined for the mu 2 subunit and alpha appendage. Using structure-directed mutagenesis, we demonstrate the ability of the beta 2 appendage alone to bind directly to clathrin and the accessory proteins AP180, epsin and eps15 at the same site. Clathrin polymerization is promoted by binding of clathrin simultaneously to the beta 2-appendage site and to a second site on the adjacent beta 2 hinge. This results in the displacement of the other ligands from the beta 2 appendage. Thus clathrin binding to an AP2-accessory protein complex would cause the controlled release of accessory proteins at sites of vesicle formation.

About this Structure

1E42 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure and function of the beta 2-adaptin appendage domain., Owen DJ, Vallis Y, Pearse BM, McMahon HT, Evans PR, EMBO J. 2000 Aug 15;19(16):4216-27. PMID:10944104 Page seeded by OCA on Fri May 2 14:38:15 2008

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