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1iju

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Revision as of 07:44, 7 April 2021

HUMAN BETA-DEFENSIN-1

Structural highlights

1iju is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DEFB1_HUMAN] Has bactericidal activity (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Defensins are a class of small cationic peptides found in higher organisms that serve as both antimicrobial and cell signaling molecules. The exact mechanism of the antimicrobial activity of defensins is not known, but two models have been postulated, one involving pore formation and the other involving nonspecific electrostatic interaction with the bacterial membrane. Here we report the high resolution structures of human beta-defensin-1 (hBD1) in two crystallographic space groups. The structure of a single molecule is very similar to that of human beta-defensin-2 (hBD2), confirming the presence of an N-terminal alpha-helix. However, while the packing of hBD1 is conserved across both space groups, there is no evidence for any larger quaternary structure similar to octameric hBD2. Furthermore, the topology of hBD1 dimers that are formed between monomers in the asymmetric unit is distinct from both hBD2 and other mammalian alpha-defensins. The structures of hBD1 and hBD2 provide a first step toward understanding the structural basis of antimicrobial and chemotactic properties of human beta-defensins.

The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.,Hoover DM, Chertov O, Lubkowski J J Biol Chem. 2001 Oct 19;276(42):39021-6. Epub 2001 Aug 2. PMID:11486002^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hoover DM, Chertov O, Lubkowski J. The structure of human beta-defensin-1: new insights into structural properties of beta-defensins. J Biol Chem. 2001 Oct 19;276(42):39021-6. Epub 2001 Aug 2. PMID:11486002 doi:10.1074/jbc.M103830200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1iju"

@@ Line 3: / Line 3: @@
 <StructureSection load='1iju' size='340' side='right'caption='[[1iju]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1iju]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1iju]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJU FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iju OCA], [http://pdbe.org/1iju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iju RCSB], [http://www.ebi.ac.uk/pdbsum/1iju PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iju ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iju OCA], [https://pdbe.org/1iju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iju RCSB], [https://www.ebi.ac.uk/pdbsum/1iju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iju ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DEFB1_HUMAN DEFB1_HUMAN]] Has bactericidal activity (By similarity).
+[[https://www.uniprot.org/uniprot/DEFB1_HUMAN DEFB1_HUMAN]] Has bactericidal activity (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1iju

From Proteopedia

Revision as of 07:44, 7 April 2021

HUMAN BETA-DEFENSIN-1

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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