1a6a
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(New page: 200px<br /> <applet load="1a6a" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a6a, resolution 2.75Å" /> '''THE STRUCTURE OF AN...)
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Revision as of 13:49, 12 November 2007
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THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3
Overview
A complex between HLA-DR3 and a fragment of invariant chain called CLIP, was isolated from a human cell line defective in antigen presentation and, its X-ray crystal structure determined. Previous data indicate that this, complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes., The structure shows that the CLIP fragment binds to DR3 in a way almost, identical to that in which antigenic peptides bind class II, histocompatibility glycoproteins. The structure is the substrate for the, loading of antigenic peptides by an exchange process catalysed by DM.
About this Structure
1A6A is a Protein complex structure of sequences from Homo sapiens with NAG as ligand. Full crystallographic information is available from OCA.
Reference
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3., Ghosh P, Amaya M, Mellins E, Wiley DC, Nature. 1995 Nov 30;378(6556):457-62. PMID:7477400
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