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2jwe
From Proteopedia
(Difference between revisions)
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==Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping== | ==Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping== | ||
| - | <StructureSection load='2jwe' size='340' side='right' caption='[[2jwe]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2jwe' size='340' side='right'caption='[[2jwe]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2jwe]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2jwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWE FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwe OCA], [https://pdbe.org/2jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwe RCSB], [https://www.ebi.ac.uk/pdbsum/2jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwe ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Ji, P]] | [[Category: Ji, P]] | ||
[[Category: Shi, Y Y]] | [[Category: Shi, Y Y]] | ||
Revision as of 08:00, 7 April 2021
Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping
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Categories: Human | Large Structures | Ji, P | Shi, Y Y | Wu, J H | Wu, J W | Yang, Y S | Zhang, J H | Cell adhesion | Cell junction | Dimer | Domain swapping | Membrane | Phosphorylation | Sh3 domain | Tight junction | Tjp1 | Zo-1
