2k6g
From Proteopedia
(Difference between revisions)
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==Solution structure of the DNA binding BRCT domain from the large subunit of human Replication Factor C== | ==Solution structure of the DNA binding BRCT domain from the large subunit of human Replication Factor C== | ||
| - | <StructureSection load='2k6g' size='340' side='right' caption='[[2k6g]], [[NMR_Ensembles_of_Models | 24 NMR models]]' scene=''> | + | <StructureSection load='2k6g' size='340' side='right'caption='[[2k6g]], [[NMR_Ensembles_of_Models | 24 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2k6g]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2k6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6G FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eub|2eub]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2eub|2eub]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RFC1, RFC140 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RFC1, RFC140 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6g OCA], [https://pdbe.org/2k6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6g RCSB], [https://www.ebi.ac.uk/pdbsum/2k6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6g ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RFC1_HUMAN RFC1_HUMAN]] The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.<ref>PMID:8999859</ref> Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.<ref>PMID:8999859</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Ab, E]] | [[Category: Ab, E]] | ||
[[Category: Bonvin, A M.J J]] | [[Category: Bonvin, A M.J J]] | ||
Revision as of 08:10, 7 April 2021
Solution structure of the DNA binding BRCT domain from the large subunit of human Replication Factor C
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Categories: Human | Large Structures | Ab, E | Bonvin, A M.J J | Kobayashi, M | Siegal, G | Activator | Alternative splicing | Atp-binding | Brct | Dna binding | Dna binding protein | Dna replication | Dna-binding | Metal-binding | Nucleotide-binding | Nucleus | Phosphoprotein | Polymorphism | Protein | Replication factor c | Transcription | Transcription regulation | Zinc | Zinc-finger
