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| - | {{Large structure}}
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| | ==The Solution Structure of the Arl2 Effector, BART== | | ==The Solution Structure of the Arl2 Effector, BART== |
| - | <StructureSection load='2k9a' size='340' side='right' caption='[[2k9a]], [[NMR_Ensembles_of_Models | 50 NMR models]]' scene=''> | + | <StructureSection load='2k9a' size='340' side='right'caption='[[2k9a]], [[NMR_Ensembles_of_Models | 50 NMR models]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2k9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9A FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2k9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9A FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARL2BP, BART, BART1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARL2BP, BART, BART1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9a OCA], [http://pdbe.org/2k9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k9a RCSB], [http://www.ebi.ac.uk/pdbsum/2k9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9a ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9a OCA], [https://pdbe.org/2k9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9a RCSB], [https://www.ebi.ac.uk/pdbsum/2k9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9a ProSAT]</span></td></tr> |
| | </table> | | </table> |
| - | {{Large structure}} | |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/AR2BP_HUMAN AR2BP_HUMAN]] Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.<ref>PMID:18234692</ref> | + | [[https://www.uniprot.org/uniprot/AR2BP_HUMAN AR2BP_HUMAN]] Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.<ref>PMID:18234692</ref> |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Human]] | | [[Category: Human]] |
| | + | [[Category: Large Structures]] |
| | [[Category: Bailey, L K]] | | [[Category: Bailey, L K]] |
| | [[Category: Campbell, L J]] | | [[Category: Campbell, L J]] |
| Structural highlights
Function
[AR2BP_HUMAN] Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The ADP-ribosylation factor-like (Arl) family of small G proteins are involved in the regulation of diverse cellular processes. Arl2 does not appear to be membrane localized and has been implicated as a regulator of microtubule dynamics. The downstream effector for Arl2, Binder of Arl 2 (BART) has no known function but, together with Arl2, can enter mitochondria and bind the adenine nucleotide transporter. We have solved the solution structure of BART and show that it forms a novel fold composed of six alpha-helices that form three interlocking "L" shapes. Analysis of the backbone dynamics reveals that the protein is highly anisotropic and that the loops between the central helices are dynamic. The regions involved in the binding of Arl2 were mapped onto the surface of BART and are found to localize to these loop regions. BART has faces of differing charge and structural elements, which may explain how it can interact with other proteins.
The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function.,Bailey LK, Campbell LJ, Evetts KA, Littlefield K, Rajendra E, Nietlispach D, Owen D, Mott HR J Biol Chem. 2009 Jan 9;284(2):992-9. Epub 2008 Nov 3. PMID:18981177[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Muromoto R, Sekine Y, Imoto S, Ikeda O, Okayama T, Sato N, Matsuda T. BART is essential for nuclear retention of STAT3. Int Immunol. 2008 Mar;20(3):395-403. doi: 10.1093/intimm/dxm154. Epub 2008 Jan, 29. PMID:18234692 doi:http://dx.doi.org/10.1093/intimm/dxm154
- ↑ Bailey LK, Campbell LJ, Evetts KA, Littlefield K, Rajendra E, Nietlispach D, Owen D, Mott HR. The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function. J Biol Chem. 2009 Jan 9;284(2):992-9. Epub 2008 Nov 3. PMID:18981177 doi:10.1074/jbc.M806167200
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