Induced fit
From Proteopedia
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*A morph of induced fit when [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza#Tamiflu_Binds_to_N1_by_Induced_Fit|Tamiflu binds to Neuraminidase]]. | *A morph of induced fit when [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza#Tamiflu_Binds_to_N1_by_Induced_Fit|Tamiflu binds to Neuraminidase]]. | ||
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Revision as of 15:29, 13 April 2021
Induced fit describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classical example of induced fit is binding of glucose to hexokinase, depicted in a morph between 3o8m and 3o80 below.
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History of the concept
Induced fit was suggested by Koshland in 1958 [1], providing an alternative to the lock-and-key binding model that Emil Fischer proposed in 1899 [2].
Interactive examples
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See Also
- A morph of induced fit when Tamiflu binds to Neuraminidase.
