User:Justin Smith/Sandbox 1

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== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<ref name="wang">PMID:32433610</ref>.
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==Tunnels==
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DGAT consists of 3 tunnels, a cytosolic tunnel, an ER-luminal funnel, and a membrane-embedded lateral gate. The cytosolic tunnel is the site of acyl-CoA binding, with the CoA group pointing at the cytosolic face and its acyl chain pointing towards the endoplasmic reticulum lumen. DAG then enters via the lateral gate on the luminal side via the lateral gate where it can then access the active site. The resulting product can then be released to either side of the membrane.
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== References ==
== References ==
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<ref name="wang">PMID:32433610</ref>.
+
 
<ref name="Sui">PMID:32433611</ref>.
<ref name="Sui">PMID:32433611</ref>.

Revision as of 19:05, 13 April 2021

Contents

DGAT Homo Sapien

Caption for this structure

Drag the structure with the mouse to rotate

Disease

Active Site

is the active base catalytic function

Relevance

Mecanism

Figure 1. Mecanism of base catalyized reaction
Figure 1. Mecanism of base catalyized reaction

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.[1].

Tunnels

DGAT consists of 3 tunnels, a cytosolic tunnel, an ER-luminal funnel, and a membrane-embedded lateral gate. The cytosolic tunnel is the site of acyl-CoA binding, with the CoA group pointing at the cytosolic face and its acyl chain pointing towards the endoplasmic reticulum lumen. DAG then enters via the lateral gate on the luminal side via the lateral gate where it can then access the active site. The resulting product can then be released to either side of the membrane.

References

[2].

Rodriguez, A. M. (2020). Zooming in on the architecture of DGAT1, a transmembrane lipid factory. Baylor College of Medicine.

Stone, S. J. Mammalian Diacylglycerol Acyltransferases (DGAT). AOCS Lipid Library.

  1. ↑ Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020 May;581(7808):329-332. doi: 10.1038/s41586-020-2280-2. Epub 2020 May, 13. PMID:32433610 doi:http://dx.doi.org/10.1038/s41586-020-2280-2
  2. ↑ Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV Jr. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 2020 May;581(7808):323-328. doi: 10.1038/s41586-020-2289-6. Epub 2020 May, 13. PMID:32433611 doi:http://dx.doi.org/10.1038/s41586-020-2289-6

Student Contributers

  • Justin Smith

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Justin Smith

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