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1a7x
From Proteopedia
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(New page: 200px<br /> <applet load="1a7x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a7x, resolution 2.0Å" /> '''FKBP12-FK1012 COMPLE...)
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Revision as of 13:50, 12 November 2007
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FKBP12-FK1012 COMPLEX
Overview
A ligand that simultaneously binds two proteins must have two high, affinity protein binding domains joined in a fashion that facilitates, or, at least does not prevent, protein-protein interaction. Designing such, ligands is challenging, and a high resolution X-ray structure of, FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.
About this Structure
1A7X is a Single protein structure of sequence from Homo sapiens with FKA as ligand. Active as Peptidylprolyl isomerase, with EC number 5.2.1.8 Full crystallographic information is available from OCA.
Reference
Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12., Schultz LW, Clardy J, Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID:9871618
Page seeded by OCA on Mon Nov 12 15:56:33 2007
